University of Technology Sydney, School of Life Sciences, NSW 2007, Sydney, Australia.
University of Technology Sydney, School of Life Sciences, NSW 2007, Sydney, Australia.
Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109757. doi: 10.1016/j.msec.2019.109757. Epub 2019 May 24.
Post-operative infection often occurs following orthopedic and dental implant placement requiring systemically administered antibiotics. However, this does not provide long-term protection. Over the last few decades, alternative methods involving slow drug delivery systems based on biodegradable poly-lactic acid and antibiotic loaded hydroxyapatite microspheres were developed to prevent post-operative infection. In this study, thermally anodised and untreated Ti6Al4V discs were coated with Poly-Lactic Acid (PLA) containing Gentamicin (Gm) antibiotic-loaded coralline Hydroxyapatite (HAp) are investigated. Following chemical characterization, mechanical properties of the coated samples were measured using nanoindentation and scratch tests to determine the elastic modulus, hardness and bonding adhesion between film and substrate. It was found that PLA biocomposite multilayered films were around 400nm thick and the influence and effect of the substrate were clearly observed during the nanoindentation studies with heavier loads. Scratch tests of PLA coated samples conducted at ~160nm depth showed the minimal difference in the measured friction between Gm and non Gm containing films. It is also observed that the hardness values of PLA film coated anodised samples ranged from 0.45 to 1.9GPa (dependent on the applied loads) against untreated coated samples which ranged from 0.28 to 0.8GPa.
骨科和牙科植入物放置后常发生术后感染，需要全身给予抗生素。然而，这并不能提供长期的保护。在过去的几十年中，已经开发出了替代方法，涉及基于可生物降解的聚乳酸和载抗生素羟基磷灰石微球的缓慢药物输送系统，以预防术后感染。在这项研究中，对经过热阳极氧化处理和未经处理的 Ti6Al4V 圆盘进行了涂层处理，其中包含载有庆大霉素（Gm）的聚乳酸（PLA）抗生素负载珊瑚羟基磷灰石（HAp）。在进行化学特性表征后，使用纳米压痕和划痕测试测量了涂层样品的机械性能，以确定弹性模量、硬度和薄膜与基底之间的结合附着力。结果发现，PLA 生物复合材料多层膜的厚度约为 400nm，并且在纳米压痕研究中，在较重的载荷下，明显观察到了基底的影响和作用。在约 160nm 深度进行的 PLA 涂层样品的划痕测试表明，载有 Gm 和不含 Gm 的薄膜之间的测量摩擦差异最小。还观察到，经过阳极氧化处理的 PLA 膜涂层样品的硬度值范围为 0.45 至 1.9GPa（取决于所施加的载荷），而未经处理的涂层样品的硬度值范围为 0.28 至 0.8GPa。
