Burdușel Alexandra-Cristina, Gherasim Oana, Andronescu Ecaterina, Grumezescu Alexandru Mihai, Ficai Anton
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.
Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomiștilor Street, 077125 Magurele, Romania.
Pharmaceutics. 2022 Mar 31;14(4):770. doi: 10.3390/pharmaceutics14040770.
Modern biomedicine aims to develop integrated solutions that use medical, biotechnological, materials science, and engineering concepts to create functional alternatives for the specific, selective, and accurate management of medical conditions. In the particular case of tissue engineering, designing a model that simulates all tissue qualities and fulfills all tissue requirements is a continuous challenge in the field of bone regeneration. The therapeutic protocols used for bone healing applications are limited by the hierarchical nature and extensive vascularization of osseous tissue, especially in large bone lesions. In this regard, nanotechnology paves the way for a new era in bone treatment, repair and regeneration, by enabling the fabrication of complex nanostructures that are similar to those found in the natural bone and which exhibit multifunctional bioactivity. This review aims to lay out the tremendous outcomes of using inorganic nanoparticles in bone healing applications, including bone repair and regeneration, and modern therapeutic strategies for bone-related pathologies.
现代生物医学旨在开发综合解决方案，利用医学、生物技术、材料科学和工程学概念，为特定、选择性和准确管理医疗状况创造功能性替代方案。在组织工程的特定情况下，设计一个模拟所有组织特性并满足所有组织要求的模型，是骨再生领域持续面临的挑战。用于骨愈合应用的治疗方案受到骨组织分层性质和广泛血管化的限制，尤其是在大的骨缺损中。在这方面，纳米技术为骨治疗、修复和再生的新时代铺平了道路，通过制造与天然骨中发现的结构相似且具有多功能生物活性的复杂纳米结构。本综述旨在阐述在骨愈合应用中使用无机纳米颗粒的巨大成果，包括骨修复和再生，以及针对骨相关病症的现代治疗策略。
