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ELAVL1 Elevates Insights: The Ups and Downs of Regulated mRNA Translation in the Control of Gonadotropin Release.

作者信息

MacNicol Angus M, Odle Angela K, Childs Gwen V

机构信息

Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

出版信息

Endocrinology. 2019 Oct 1;160(10):2466-2468. doi: 10.1210/en.2019-00524.

DOI:10.1210/en.2019-00524
PMID:31504402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6760528/
Abstract
摘要

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The RNA-Binding Protein ELAVL1 Regulates GnRH Receptor Expression and the Response to GnRH.ELAVL1 蛋白作为 RNA 结合蛋白调控 GnRH 受体的表达和对 GnRH 的反应。
Endocrinology. 2019 Aug 1;160(8):1999-2014. doi: 10.1210/en.2019-00203.
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Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.肌球蛋白与多聚（A）结合蛋白的相互作用对于靶 mRNA 翻译的激活是必需的。
J Biol Chem. 2019 Jul 12;294(28):10969-10986. doi: 10.1074/jbc.RA119.007220. Epub 2019 May 31.
3
Emerging Evidence of Translational Control by AU-Rich Element-Binding Proteins.富含AU元件结合蛋白介导翻译调控的新证据
Front Genet. 2019 May 2;10:332. doi: 10.3389/fgene.2019.00332. eCollection 2019.
4
The AU-rich element landscape across human transcriptome reveals a large proportion in introns and regulation by ELAVL1/HuR.AU 富元素景观横跨人类转录组，揭示了大量内含子和 ELAVL1/HuR 调节的存在。
Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):167-177. doi: 10.1016/j.bbagrm.2017.12.006. Epub 2018 Feb 2.
5
Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence.瘦素对促性腺激素细胞促性腺激素释放激素受体的调节作为代谢检查点和生殖能力的门户
Front Endocrinol (Lausanne). 2018 Jan 5;8:367. doi: 10.3389/fendo.2017.00367. eCollection 2017.
6
Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression.促性腺激素释放激素受体信使核糖核酸与干细胞决定因子马斯ashi的关联：瘦素介导的促性腺激素释放激素受体表达调节机制
Endocrinology. 2018 Feb 1;159(2):883-894. doi: 10.1210/en.2017-00586.
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Nat Genet. 2017 Jun;49(6):866-875. doi: 10.1038/ng.3854. Epub 2017 Apr 24.
8
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Front Biosci (Landmark Ed). 2012 Jan 1;17(1):189-205. doi: 10.2741/3921.
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Cell Mol Life Sci. 2008 Oct;65(20):3168-81. doi: 10.1007/s00018-008-8252-6.
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