Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Front Endocrinol (Lausanne). 2020 Sep 10;11:656. doi: 10.3389/fendo.2020.00656. eCollection 2020.
The mechanisms that mediate plasticity in pituitary function have long been a subject of vigorous investigation. Early studies overcame technical barriers and challenged conceptual barriers to identify multipotential and multihormonal cell populations that contribute to diverse pituitary stress responses. Decades of intensive study have challenged the standard model of dedicated, cell type-specific hormone production and have revealed the malleable cellular fates that mediate pituitary responses. Ongoing studies at all levels, from animal physiology to molecular analyses, are identifying the mechanisms underlying this cellular plasticity. This review describes the findings from these studies that utilized state-of-the-art tools and techniques to identify mechanisms of plasticity throughout the pituitary and focuses on the insights brought to our understanding of pituitary function.
长期以来，介导垂体功能可塑性的机制一直是激烈研究的主题。早期的研究克服了技术障碍，并挑战了概念障碍，以确定有助于不同垂体应激反应的多潜能和多激素细胞群体。几十年来的深入研究挑战了专门的、细胞类型特异性激素产生的标准模型，并揭示了介导垂体反应的可塑细胞命运。从动物生理学到分子分析的各个层面的正在进行的研究正在确定这种细胞可塑性的基础机制。这篇综述描述了这些研究的发现，这些研究利用最先进的工具和技术来确定整个垂体的可塑性机制，并侧重于这些发现为我们对垂体功能的理解带来的见解。
