Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Department of Neurology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Eur J Public Health. 2020 Feb 1;30(1):164-170. doi: 10.1093/eurpub/ckz142.
The study was conducted to evaluate the independent dose-response of the night sleep duration and sleep initiation time on hypertension, and to explore their combined effect with hypertension.
Participants from the Henan Rural Cohort were enrolled in this study. Information on sleep was collected using the Pittsburgh Sleep Quality Index. Hypertension was defined as systolic blood pressure/diastolic blood pressure ≥140/90 mmHg or self-reported hypertension and current use of anti-hypertensive medicines. Logistic regression and restricted cubic spline were conducted to evaluate the association of night sleep duration and sleep initiation time with hypertension.
Of the 37 317 included participants, 12 333 suffered from hypertension. 14 474 (38.79%) were men and 22 843 (61.21%) were women, the mean age were 57.18 ± 12.10 and 55.24 ± 11.98 in men and women. Compared to reference (7-h), fully adjusted odd ratios (ORs) and 95% confidence interval (CI) of hypertension were 0.91 (0.66-1.25) in <5 h group and 1.74 (1.41-2.16) in ≥10 h among men, respectively. Fully adjusted ORs (95% CIs) for hypertension compared with reference (21:00-22:00) were 1.05 (95% CI 0.78-1.41) in the <20:00 group, 1.52 (1.25-1.85) in ≥24:00 in men. The combined effect of sleep duration and sleep initiation time on hypertension were statistically significant in the category of (≥8 h)/night and ≥24:00 (OR 1.87, 95% CI 1.07-3.25) compared to reference in fully adjusted model among men.
Long night sleep duration and late sleep initiation time were associated with the higher odds of hypertension, and the sleep duration and sleep initiation time might cumulatively increase the prevalence of hypertension in men.
The Henan Rural Cohort Study has been registered at the Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). http://www.chictr.org.cn/showproj.aspx? proj=11375.
本研究旨在评估夜间睡眠时间和入睡时间对高血压的独立剂量反应，并探讨其与高血压的综合效应。
本研究纳入了来自河南农村队列的参与者。使用匹兹堡睡眠质量指数收集睡眠信息。高血压定义为收缩压/舒张压≥140/90mmHg 或自我报告高血压且正在使用抗高血压药物。采用 logistic 回归和限制立方样条分析评估夜间睡眠时间和入睡时间与高血压的关系。
在纳入的 37317 名参与者中，有 12333 人患有高血压。14474 名（38.79%）为男性，22843 名（61.21%）为女性，男性和女性的平均年龄分别为 57.18±12.10 岁和 55.24±11.98 岁。与参考值（7 小时）相比，男性睡眠时间<5 小时组的高血压比值比（OR）和 95%置信区间（CI）为 0.91（0.66-1.25），睡眠时间≥10 小时组为 1.74（1.41-2.16）。与参考值（21:00-22:00）相比，男性睡眠时间<20:00 组的高血压比值比（OR）为 1.05（95%CI 0.78-1.41），睡眠时间≥24:00 组为 1.52（1.25-1.85）。在男性中，睡眠时间和入睡时间的综合效应在（≥8 小时/夜）和≥24:00 组与参考值相比具有统计学意义（OR 1.87，95%CI 1.07-3.25）。
长夜间睡眠时间和晚入睡时间与高血压的发病风险增加有关，且睡眠时间和入睡时间可能会累积增加男性高血压的患病率。
河南农村队列研究已在中国临床试验注册中心注册（注册号：ChiCTR-OOC-15006699）。http://www.chictr.org.cn/showproj.aspx?proj=11375。
