Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Sleep Breath. 2023 Dec;27(6):2191-2198. doi: 10.1007/s11325-023-02818-z. Epub 2023 Apr 3.
Evidence has suggested the linkage between sleep habits and several metabolic diseases, but the association of sleep factors with bone health remains unclear, especially in regions with low economic levels. Thus, this study aimed to investigate the relationship of nocturnal sleep duration and sleep midpoint with the osteoporosis risk in a rural population.
Eligible subjects were derived from the Henan Rural Cohort Study. The Pittsburgh Sleep Quality Index was applied to collect sleep information including sleep initiating time and wake-up time. The bone mineral density of the calcaneus was measured by the ultrasonic bone density apparatus. Multivariable logistic regression models and restricted cubic splines were utilized to evaluate the odds ratio (OR) and 95% confidence intervals (95% CI).
For 8033 participants, 1636 subjects suffered from osteoporosis. Compared with the reference group (7 ~ h group), the ORs and 95% CI of osteoporosis associated with duration of nocturnal sleep were 1.32 (1.10, 1.56), 1.59 (1.25, 2.01), and 1.82 (1.25, 2.65) in the 8 ~ h, 9 ~ h, and ≥ 10 h group, respectively. Additionally, the adjusted ORs and 95% CI were 1.20 (1.01, 1.44) in the early sleep midpoint group and 1.09 (0.92, 1.29) in the intermediate sleep midpoint, compared with the late. Furthermore, there was a joint effect of long duration of nocturnal sleep and the early sleep midpoint on osteoporosis.
Long duration of nocturnal sleep and early sleep midpoint were independently and jointly associated with higher risk of osteoporosis in rural areas.
The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). Date of registration: 06 July 2015. http://www.chictr.org.cn/showproj.aspx?proj=11375.
有证据表明睡眠习惯与几种代谢性疾病之间存在关联，但睡眠因素与骨骼健康之间的关系尚不清楚，尤其是在经济水平较低的地区。因此，本研究旨在调查农村人群夜间睡眠时间和睡眠中点与骨质疏松症风险之间的关系。
合格的研究对象来自河南农村队列研究。匹兹堡睡眠质量指数用于收集睡眠信息，包括入睡时间和醒来时间。通过超声骨密度仪测量跟骨的骨密度。多变量逻辑回归模型和限制立方样条用于评估比值比（OR）和 95%置信区间（95%CI）。
在 8033 名参与者中，有 1636 名患有骨质疏松症。与参考组（7h 组）相比，夜间睡眠时间与骨质疏松症相关的 OR 值和 95%CI 分别为 1.32（1.10，1.56）、1.59（1.25，2.01）和 1.82（1.25，2.65）在 8h、9~h 和≥10 h 组中。此外，早睡中点组的调整后 OR 值和 95%CI 为 1.20（1.01，1.44），而晚睡中点组的调整后 OR 值和 95%CI 为 1.09（0.92，1.29）。此外，夜间睡眠时间长和早睡中点有联合作用，与骨质疏松症风险增加相关。
农村地区夜间睡眠时间长和早睡中点与骨质疏松症风险增加独立且共同相关。
河南农村队列研究已在中国临床试验注册中心注册（注册号：ChiCTR-OOC-15006699）。注册日期：2015 年 7 月 6 日。http://www.chictr.org.cn/showproj.aspx?proj=11375。
