Burn Treatment Center, Dr. José Frota Institute, Fortaleza, CE, Brazil.
Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
J Burn Care Res. 2020 Feb 19;41(2):241-247. doi: 10.1093/jbcr/irz149.
This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children. This is an open-label, monocentric, randomized phase II pilot study conducted in Fortaleza, Brazil. The study population consisted of 30 children between the ages of 2 and 12 years with superficial "partial-thickness" burns admitted less than 72 hours from the thermal injury. In the test group, the tilapia skin was applied. In the control group, a thin layer of silver sulfadiazine cream 1% was applied. Tilapia skin showed good adherence to the wound bed, reducing the number of dressing changes required, the amount of anesthetics used, and providing benefits for the patients and also for healthcare professionals, by reducing the overall work load. The number of days to complete burn wound healing, the total amount of analgesics required throughout the treatment, burn improvement on the day of dressing removal, and pain throughout the treatment were similar to the conventional treatment with silver sulfadiazine. Thus, tilapia skin can be considered an effective and low-cost extra resource in the therapeutic arsenal of pediatric superficial partial thickness burns.
本研究旨在评估尼罗罗非鱼皮作为儿童部分厚度烧伤治疗的异种移植物的疗效。这是一项在巴西福塔雷萨进行的开放标签、单中心、随机二期试点研究。研究人群包括 30 名年龄在 2 至 12 岁之间的儿童，他们在热损伤后不到 72 小时内患有浅表“部分厚度”烧伤。在试验组中，使用了罗非鱼皮。在对照组中，使用了 1%磺胺嘧啶银乳膏的薄层。罗非鱼皮与伤口床贴合良好，减少了所需的换敷料次数，减少了麻醉剂的使用量，为患者和医疗保健专业人员提供了益处，减轻了整体工作负担。完成烧伤创面愈合所需的天数、整个治疗过程中所需的镇痛药总量、敷料去除当天的烧伤改善情况以及整个治疗过程中的疼痛与传统的磺胺嘧啶银治疗相似。因此，罗非鱼皮可以被认为是治疗儿童浅表部分厚度烧伤的有效且低成本的额外资源。
