全麦小麦消费对超重和肥胖且伴有轻度高胆固醇血症的 Graandioos 研究中成年人的餐后炎症反应有影响：一项随机对照试验。
Whole Grain Wheat Consumption Affects Postprandial Inflammatory Response in a Randomized Controlled Trial in Overweight and Obese Adults with Mild Hypercholesterolemia in the Graandioos Study.
机构信息
TNO, Netherlands Organization for Applied Scientific Research, Zeist, Netherlands.
Wageningen University, Division of Human Nutrition, Wageningen, Netherlands.
出版信息
J Nutr. 2019 Dec 1;149(12):2133-2144. doi: 10.1093/jn/nxz177.
BACKGROUND
Whole grain wheat (WGW) consumption is associated with health benefits in observational studies. However, WGW randomized controlled trial (RCT) studies show mixed effects.
OBJECTIVES
The health impact of WGW consumption was investigated by quantification of the body's resilience, which was defined as the "ability to adapt to a standardized challenge."
METHODS
A double-blind RCT was performed with overweight and obese (BMI: 25-35 kg/m2) men (n = 19) and postmenopausal women (n = 31) aged 45-70 y, with mildly elevated plasma total cholesterol (>5 mmol/L), who were randomly assigned to either 12-wk WGW (98 g/d) or refined wheat (RW). Before and after the intervention a standardized mixed-meal challenge was performed. Plasma samples were taken after overnight fasting and postprandially (30, 60, 120, and 240 min). Thirty-one biomarkers were quantified focusing on metabolism, liver, cardiovascular health, and inflammation. Linear mixed-models evaluated fasting compared with postprandial intervention effects. Health space models were used to evaluate intervention effects as composite markers representing resilience of inflammation, liver, and metabolism.
RESULTS
Postprandial biomarker changes related to liver showed decreased alanine aminotransferase by WGW (P = 0.03) and increased β-hydroxybutyrate (P = 0.001) response in RW. Postprandial changes related to inflammation showed increased C-reactive protein (P = 0.001), IL-6 (P = 0.02), IL-8 (P = 0.007), and decreased IL-1B (P = 0.0002) in RW and decreased C-reactive protein (P < 0.0001), serum amyloid A (P < 0.0001), IL-8 (P = 0.02), and IL-10 (P < 0.0001) in WGW. Health space visualization demonstrated diminished inflammatory (P < 0.01) and liver resilience (P < 0.01) by RW, whereas liver resilience was rejuvenated by WGW (P < 0.05).
CONCLUSIONS
Twelve-week 98 g/d WGW consumption can promote liver and inflammatory resilience in overweight and obese subjects with mildly elevated plasma cholesterol. The health space approach appeared appropriate to evaluate intervention effects as composite markers. This trial was registered at www.clinicaltrials.gov as NCT02385149.
背景
全谷物小麦（WGW）的消费与观察性研究中的健康益处有关。然而，WGW 随机对照试验（RCT）研究显示出混合效应。
目的
通过量化身体的弹性来研究 WGW 消费的健康影响，弹性定义为“适应标准化挑战的能力”。
方法
对超重和肥胖（BMI：25-35 kg/m2）的男性（n=19）和绝经后女性（n=31）进行了一项双盲 RCT，年龄在 45-70 岁之间，血浆总胆固醇水平略高（>5 mmol/L），随机分配至 12 周 WGW（98 g/d）或精制小麦（RW）组。干预前后进行了标准化混合餐挑战。在禁食过夜和餐后（30、60、120 和 240 分钟）时采集血浆样本。定量了 31 种生物标志物，重点关注代谢、肝脏、心血管健康和炎症。线性混合模型评估了空腹与餐后干预效果。使用健康空间模型评估干预效果，作为代表炎症、肝脏和代谢弹性的综合标志物。
结果
与肝脏相关的餐后生物标志物变化显示，WGW 降低了丙氨酸氨基转移酶（P=0.03），RW 增加了β-羟基丁酸（P=0.001）反应。与炎症相关的餐后变化显示，RW 增加了 C 反应蛋白（P=0.001）、IL-6（P=0.02）、IL-8（P=0.007）和降低了 IL-1B（P=0.0002），而 WGW 降低了 C 反应蛋白（P<0.0001）、血清淀粉样蛋白 A（P<0.0001）、IL-8（P=0.02）和 IL-10（P<0.0001）。健康空间可视化显示 RW 降低了炎症（P<0.01）和肝脏弹性（P<0.01），而 WGW 促进了肝脏弹性（P<0.05）。
结论
12 周 98 g/d WGW 消费可以促进超重和肥胖且血浆胆固醇略高的受试者的肝脏和炎症弹性。健康空间方法似乎适合作为综合标志物评估干预效果。该试验已在 www.clinicaltrials.gov 上注册，编号为 NCT02385149。
Zotero 插件