Section of Hygiene, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italia.
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Endocrine. 2021 Jan;71(1):233-241. doi: 10.1007/s12020-020-02464-5. Epub 2020 Aug 31.
Neuroendocrine neoplasia (NEN) has been displaying an incremental trend along the last two decades. This phenomenon is poorly understood, and little information is available on risk factor for neuroendocrine neoplasia development. Aim of this work is to elucidate the role of potentially modifiable risk factors for pancreatic and pulmonary NEN.
We conducted a case-control study on 184 patients with NEN (100 pancreas and 84 lung) and 248 controls. The structured questionnaire included 84 queries on socio-demographic, behavioral, dietary and clinical information.
Increased risk was associated with history of cancer ("other tumor", lung OR = 7.18; 95% CI: 2.55-20.20 and pancreas OR = 5.88; 95% CI: 2.43-14.22; "family history of tumor", lung OR = 2.66; 95% CI: 1.53-4.64 and pancreas OR = 1.94; 95% CI: 1.19-3.17; "family history of lung tumor", lung OR = 2.56; 95% CI: 1.05-6.24 and pancreas OR = 2.60; 95% CI: 1.13-5.95). Type 2 diabetes mellitus associated with an increased risk of pancreatic NEN (OR = 3.01; 95% CI: 1.15-7.89).
Besides site-specific risk factors, there is a significant link between neuroendocrine neoplasia and cancer in general, pointing to a shared cancer predisposition.
神经内分泌肿瘤（NEN）在过去二十年中呈现出递增趋势。这种现象尚未被充分理解，有关神经内分泌肿瘤发展的危险因素的信息也很少。本研究旨在阐明胰腺和肺神经内分泌肿瘤的潜在可改变危险因素的作用。
我们对 184 名 NEN 患者（100 名胰腺和 84 名肺）和 248 名对照进行了病例对照研究。结构化问卷包括 84 个关于社会人口统计学、行为、饮食和临床信息的问题。
癌症史（“其他肿瘤”，肺 OR=7.18；95%CI：2.55-20.20 和胰腺 OR=5.88；95%CI：2.43-14.22；“肿瘤家族史”，肺 OR=2.66；95%CI：1.53-4.64 和胰腺 OR=1.94；95%CI：1.19-3.17；“肺癌家族史”，肺 OR=2.56；95%CI：1.05-6.24 和胰腺 OR=2.60；95%CI：1.13-5.95）与风险增加相关。2 型糖尿病与胰腺 NEN 的风险增加相关（OR=3.01；95%CI：1.15-7.89）。
除了特定部位的危险因素外，神经内分泌肿瘤与一般癌症之间存在显著关联，表明存在共同的癌症易感性。
