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凝集素免疫组织化学在关节疾病中的应用。

Use of lectin-immunohistochemistry in joint diseases.

作者信息

Fritz P, Tuczek H V, Hoenes J, Mischlinski A, Grau A, Hage C, Koenig A, Wegner G

机构信息

Robert-Bosch-Krankenhaus, Pathologische Abteilung, Stuttgart.

出版信息

Acta Histochem Suppl. 1988;36:277-83.

PMID:3150561
Abstract

The lectin binding pattern of the inflamed synovial tissue of patients with OA (osteoarthritis) and RA (rheumatoid arthritis) were examined with 18 different lectins. The synovial lining cells are heavily stained by PHA-L, WGA, PNA, Con A, MPA and RCA. In the subsynovial layer, WGA, PHA-L and RCA were found to be fairly good monocytic markers. The lectin binding pattern of the lectins under study, however, failed to discriminate between patients with OA and RA.

摘要

用18种不同的凝集素检测了骨关节炎(OA)和类风湿关节炎(RA)患者炎症滑膜组织的凝集素结合模式。滑膜衬里细胞被PHA-L、WGA、PNA、Con A、MPA和RCA重度染色。在滑膜下层,发现WGA、PHA-L和RCA是相当好的单核细胞标志物。然而,所研究的凝集素的凝集素结合模式未能区分OA患者和RA患者。

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