Rastegar-Kashkouli Ali, Khaledi Azad, Moammer Farzaneh, Ghenaatpisheh Sanani Mohammad, Mahdi Heidari Mohammad, Foroughi Eghbal Aynaz
Isfahan University of Medical Sciences School of Medicine, Isfahan, Iran.
Infectious Diseases Reaserch Center, Kashan University of Medical Sciences, Kashan, Iran.
Eurasian J Med. 2024 May 9;56(3):189-198. doi: 10.5152/eurasianjmed.2024.23302.
This study aimed to conduct a retrospective Middle East systematic review and meta-analysis on the prevalence and antibiotic susceptibility pattern for this microorganism isolated from cystic fibrosis patients. We searched MEDLINE, the Cochrane Library, SCOPUS, and Web of Science (ISI) to identify studies that reported the prevalence of Pseudomonas aeruginosa isolated from cystic fibrosis (CF) patients, and antibiotic resistance patterns. To assess the quality of publications was used of a checklist provided by the Joanna Briggs Institute. Finally, the data was analyzed by comprehensive meta-analysis software. The studied populations comprised children and young, and adult CF patients. Patients were aged between 3 months-65 years. A higher percentage of CF patients were males. Pseudomonas aeruginosa frequency varied between 5.9 and 76.2% in the studies included. The combined prevalence of P. aeruginosa was reported 34.3%. The lowest level resistance of P. aeruginosa was toward colistin (0%-13.3%) and ticarcillin (3.9%-24%). Our study showed the prevalence of P. aeruginosa and antibiotic resistance are almost high, while colistin and ticarcillin are the best antibiotics to decrease postantibiotic efects (PAEs) in CF patients from the Middle East. Therefore, physicians should pay more attention to therapeutic protocols to prevent further resistance.
本研究旨在对从囊性纤维化患者中分离出的这种微生物的患病率及抗生素敏感性模式进行一项回顾性中东系统评价和荟萃分析。我们检索了MEDLINE、Cochrane图书馆、SCOPUS和科学网（ISI），以确定报告从囊性纤维化（CF）患者中分离出铜绿假单胞菌的患病率及抗生素耐药模式的研究。使用乔安娜·布里格斯研究所提供的清单来评估出版物的质量。最后，通过综合荟萃分析软件对数据进行分析。研究人群包括儿童、青年和成年CF患者。患者年龄在3个月至65岁之间。CF患者中男性比例较高。在纳入的研究中，铜绿假单胞菌的频率在5.9%至76.2%之间变化。据报告，铜绿假单胞菌的合并患病率为34.3%。铜绿假单胞菌对黏菌素（0%-13.3%）和替卡西林（3.9%-24%）的耐药水平最低。我们的研究表明，中东CF患者中铜绿假单胞菌的患病率和抗生素耐药性几乎都很高，而黏菌素和替卡西林是降低抗生素后效应（PAEs）的最佳抗生素。因此，医生应更加关注治疗方案以防止进一步耐药。
