Zhang Ming-Kang, Ye Jing-Jie, Li Chu-Xin, Xia Yu, Wang Zi-Yang, Feng Jun, Zhang Xian-Zheng
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry Wuhan University Wuhan 430072 P.R. China.
Adv Sci (Weinh). 2019 Jul 1;6(17):1900835. doi: 10.1002/advs.201900835. eCollection 2019 Sep 4.
Metal ions are of significant importance in biomedical science. This study reports a new concept of cytomembrane-mediated biospecific transport of metal ions without using any other materials. For the first time, cytomembranes are exploited for two-step conjugation with metal ions to provide hybrid nanomaterials. The innate biofunction of cell membranes renders the hybrids with superior advantages over common vehicles for metal ions, including excellent biocompatibility, low immunogenic risk, and particularly specific biotargeting functionality. As a proof-of-concept demonstration, cancer cell membranes are used for in vivo delivery of various metal ions, including ruthenium, europium, iron, and manganese, providing a series of tumor-targeted nanohybrids capable of photothermal therapy/imaging, magnetic resonance imaging, photoacoustic imaging, and fluorescence imaging with improved performances. In addition, the special structure of the cell membrane allows easy accommodation of small-molecular agents within the nanohybrids for effective chemotherapy. This study provides a new class of metal-ion-included nanomaterials with versatile biofunctions and offers a novel solution to address the important challenge in the field of in vivo targeted delivery of metal ions.
金属离子在生物医学科学中具有重要意义。本研究报道了一种无需使用任何其他材料的细胞膜介导的金属离子生物特异性运输新概念。首次利用细胞膜与金属离子进行两步共轭以提供杂化纳米材料。细胞膜的固有生物功能使这些杂化物相对于常见的金属离子载体具有卓越优势，包括出色的生物相容性、低免疫原性风险，尤其是特定的生物靶向功能。作为概念验证演示，癌细胞膜用于体内递送包括钌、铕、铁和锰在内的各种金属离子，提供了一系列具有改进性能的能够用于光热治疗/成像、磁共振成像、光声成像和荧光成像的肿瘤靶向纳米杂化物。此外，细胞膜的特殊结构允许小分子药物轻松容纳于纳米杂化物中以进行有效的化疗。本研究提供了一类具有多功能生物功能的含金属离子纳米材料，并为解决金属离子体内靶向递送领域的重要挑战提供了一种新的解决方案。
