肿瘤衍生膜泡：个性化免疫治疗的有前景工具。

Xu Jiabin, Cao Wenqiang, Wang Penglai, Liu Hong

School of Stomatology, Xuzhou Medical University, Xuzhou 221004, China.

Affiliated Stomatological Hospital of Xuzhou Medical University, Xuzhou 221004, China.

Pharmaceuticals (Basel). 2022 Jul 16;15(7):876. doi: 10.3390/ph15070876.

Tumor-derived membrane vesicles (TDMVs) are non-invasive, chemotactic, easily obtained characteristics and contain various tumor-borne substances, such as nucleic acid and proteins. The unique properties of tumor cells and membranes make them widely used in drug loading, membrane fusion and vaccines. In particular, personalized vectors prepared using the editable properties of cells can help in the design of personalized vaccines. This review focuses on recent research on TDMV technology and its application in personalized immunotherapy. We elucidate the strengths and challenges of TDMVs to promote their application from theory to clinical practice.

肿瘤衍生膜泡（TDMVs）具有非侵入性、趋化性、易于获取等特点，且含有多种肿瘤源性物质，如核酸和蛋白质。肿瘤细胞及膜的独特性质使其在药物装载、膜融合和疫苗方面得到广泛应用。特别是利用细胞的可编辑特性制备的个性化载体有助于个性化疫苗的设计。本综述聚焦于TDMV技术的最新研究及其在个性化免疫治疗中的应用。我们阐明了TDMVs的优势与挑战，以推动其从理论到临床实践的应用。