Chen Hang, Liu Tianjiao, Su Zhiqiang, Shang Li, Wei Gang
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 100029 Beijing, China.
Nanoscale Horiz. 2018 Mar 1;3(2):74-89. doi: 10.1039/c7nh00158d. Epub 2017 Nov 8.
Two-dimensional (2D) graphene-like nanomaterials show wide applications in the fields of nanodevices, sensors, energy materials, catalysis, drug delivery, bioimaging, and tissue engineering. Recently, many studies have been focused on the synthesis and application of 2D transition metal dichalcogenide (TMD) nanosheets for various biomedical applications. In particular, 2D TMD nanosheets exhibit great advantages for tumor imaging and therapy compared to some traditional nanomaterials due to their high specific surface area, good biocompatibility, easy modification, and ultrahigh light and heat conversion efficiency. In this review, we summarize the recent advances in the synthesis, modification, and photo/thermo-based tumor imaging and therapy of 2D TMD nanosheets. The important studies on tumor bioimaging with TMD nanosheets, such as X-ray computed tomography, magnetic resonance imaging, and photoacoustic imaging, are demonstrated and discussed. In another section, the physical photothermal and photodynamic therapies as well as the pharmacological therapy of tumors with TMD nanosheet-based nanohybrids are introduced. It is expected that this work will be valuable for readers to understand the synthesis and modification of TMD nanosheets to design novel 2D functional nanomaterials for photo/thermo-based tumor imaging and therapy in one aspect, and in another aspect will extend the applications of TMD-based nanomaterials in materials science, analytical science, electrocatalysis, tissue engineering, and others.
二维（2D）类石墨烯纳米材料在纳米器件、传感器、能源材料、催化、药物递送、生物成像和组织工程等领域有着广泛应用。近年来，许多研究聚焦于二维过渡金属二硫属化物（TMD）纳米片在各种生物医学应用中的合成与应用。特别是，二维TMD纳米片由于其高比表面积、良好的生物相容性、易于修饰以及超高的光热转换效率，与一些传统纳米材料相比，在肿瘤成像和治疗方面展现出巨大优势。在本综述中，我们总结了二维TMD纳米片在合成、修饰以及基于光/热的肿瘤成像和治疗方面的最新进展。展示并讨论了关于TMD纳米片用于肿瘤生物成像的重要研究，如X射线计算机断层扫描、磁共振成像和光声成像。在另一部分，介绍了基于TMD纳米片的纳米杂化物对肿瘤的物理光热和光动力疗法以及药物疗法。期望这项工作一方面对读者理解TMD纳米片的合成和修饰以设计用于基于光/热的肿瘤成像和治疗的新型二维功能纳米材料有价值，另一方面将扩展基于TMD的纳米材料在材料科学、分析科学、电催化、组织工程等领域的应用。
