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一例肺小细胞癌自发消退病例

A Case of Spontaneous Regression of Pulmonary Small Cell Carcinoma.

作者信息

Ugajin Motoi, Kani Hisanori

机构信息

Department of Respiratory Medicine, Nagoya Tokushukai General Hospital, Japan.

Department of Thoracic Surgery, Nagoya Tokushukai General Hospital, Japan.

出版信息

Eur J Case Rep Intern Med. 2019 Jul 31;6(8):001203. doi: 10.12890/2019_001203. eCollection 2019.

DOI:10.12890/2019_001203
PMID:31508387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6726342/
Abstract

UNLABELLED

An 82-year-old man was examined using chest computed tomography after treatment for pneumonia. Imaging showed a nodular shadow in the left lower lobe with associated enlarged lymph nodes. A polypoid tumour was observed on bronchoscopic examination, and the histological findings showed pulmonary small cell carcinoma with infiltration of CD3-positive and CD8-positive lymphocytes. The patient declined any antitumoural therapy and experienced an exacerbation of heart failure treated with atrial natriuretic peptide. Eighteen months after the diagnosis, the polypoid tumour had disappeared. T lymphocyte-mediated immunity and the antitumoural effects of atrial natriuretic peptide may have influenced the observed spontaneous regression.

LEARNING POINTS

Spontaneous regression of pulmonary small cell carcinoma is an exceptional phenomenon.T lymphocyte-mediated immunity and the administration of atrial natriuretic peptide may have affected the observed spontaneous regression of pulmonary small cell carcinoma.

摘要

未标注

一名82岁男性在肺炎治疗后接受胸部计算机断层扫描检查。影像学显示左下叶有结节状阴影及相关淋巴结肿大。支气管镜检查发现一个息肉样肿瘤，组织学检查结果显示为肺小细胞癌，伴有CD3阳性和CD8阳性淋巴细胞浸润。患者拒绝任何抗肿瘤治疗，因心力衰竭加重接受心房利钠肽治疗。诊断后18个月，息肉样肿瘤消失。T淋巴细胞介导的免疫反应和心房利钠肽的抗肿瘤作用可能影响了观察到的自发消退。

学习要点

肺小细胞癌的自发消退是一种罕见现象。T淋巴细胞介导的免疫反应和心房利钠肽的使用可能影响了观察到的肺小细胞癌的自发消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156c/6726342/1ee4ae758e43/1203_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156c/6726342/753c7793d523/1203_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156c/6726342/b0ad77d92748/1203_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156c/6726342/9080cb3af96e/1203_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156c/6726342/1ee4ae758e43/1203_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156c/6726342/753c7793d523/1203_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156c/6726342/b0ad77d92748/1203_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156c/6726342/9080cb3af96e/1203_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156c/6726342/1ee4ae758e43/1203_Fig4.jpg

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Spontaneous regression of breast cancer with axillary lymph node metastasis: a case report and review of literature.
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