Carmo Hercules Magalhães Olivense do, Souza Feliph Miquéias Alcântara de, Soares Ana Clara Leal, Munhoz João Abner Marins, Santos Francisco Glauco de Araújo, de Siqueira Nilton Ghiotti, Silva Romeu Paulo Martins
Universidade Federal do Acre, Centro de Ciências da Saúde e do Desporto, Rio Branco, AC, Brasil.
Rev Col Bras Cir. 2019 Sep 9;46(4):e2238. doi: 10.1590/0100-6991e-20192238.
to compare the effects of the hydroalcoholic extract from the peel of Camu-Camu, a fruit plant belonging to the Myrtaceae family, widely distributed in the Amazon basin, with those of sleeve gastrectomy, on the weight and glycemia of Wistar rats.
twenty-four Wistar rats underwent obesity induction through a hyperlipid diet for eight weeks (fat period), and were randomized into three groups: Control Group (CG), Camu-Camu Group (CCG) and Bariatric Surgery Group (BSG). After this period, all animals returned to a normal diet and the intervention period began: CG did not undergo any intervention beyond diet change; CCG animals underwent gavage procedure for administration of Camu-Camu hydroalcoholic extract, 1g/kg/day, for four weeks; and the BSG was submitted to the surgical procedure of sleeve gastrectomy. We followed all animals for four weeks.
there was only one loss in BSG due to a gastric fistula. We observed significant variations in the animals' mean weight: the CG evolved with weight gain even after the withdraw of the hypercaloric diet, while the other two groups presented weight reduction. BSG presented a significant reduction of weight and BMI (p<0.05); CCG achieved a significant reduction only of the BMI (p<0.05). There were no statistically significant changes in the glycemic levels.
in spite of reducing weight, the crude hydroalcoholic extract of the Camu-Camu peel was not able to be as efficient as sleeve gastrectomy in the control of body weight in Wistar rats.
比较番荔枝科一种果实植物卡姆果（Camu-Camu）果皮的水醇提取物与袖状胃切除术对Wistar大鼠体重和血糖的影响，卡姆果广泛分布于亚马逊盆地。
24只Wistar大鼠通过高脂饮食诱导肥胖8周（脂肪期），然后随机分为三组：对照组（CG）、卡姆果组（CCG）和减重手术组（BSG）。在此期间过后，所有动物恢复正常饮食并开始干预期：CG组除饮食改变外未接受任何干预；CCG组动物接受灌胃程序，每天给予1g/kg卡姆果水醇提取物，持续四周；BSG组接受袖状胃切除术。我们对所有动物进行了四周的跟踪观察。
BSG组有一只动物因胃瘘死亡。我们观察到动物平均体重有显著变化：即使在高热量饮食撤除后，CG组体重仍继续增加，而其他两组体重减轻。BSG组体重和BMI显著降低（p<0.05）；CCG组仅BMI显著降低（p<0.05）。血糖水平无统计学显著变化。
尽管卡姆果果皮的粗水醇提取物能减轻体重，但在控制Wistar大鼠体重方面不如袖状胃切除术有效。
