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从干细胞中构建囊胚。

Building Blastocysts from Stem Cells.

机构信息

School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv, Israel.

School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv, Israel.

出版信息

Stem Cell Reports. 2019 Sep 10;13(3):437-439. doi: 10.1016/j.stemcr.2019.08.009.

DOI:10.1016/j.stemcr.2019.08.009
PMID:31509735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6742616/
Abstract

The blastocyst stage and the subsequent implantation are critical for a successful pregnancy, yet are challenging to study in vivo. In this issue of Stem Cell Reports, Kime et al. (2019) describe a novel way to generate blastocyst-like structures only from pluripotent stem cells. These structures mimic several aspects of the early embryo, offering a new promising tool to study this stage.

摘要

囊胚阶段和随后的着床对于成功妊娠至关重要，但在体内研究具有挑战性。在本期《Stem Cell Reports》杂志中，Kime 等人（2019）描述了一种仅从多能干细胞生成类囊胚结构的新方法。这些结构模拟了早期胚胎的几个方面，为研究这一阶段提供了一个新的有前途的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9518/6742616/c4fe3542ccde/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9518/6742616/c4fe3542ccde/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9518/6742616/c4fe3542ccde/gr1.jpg

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2
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本文引用的文献

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Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells.诱导多能干细胞形成具有 2C 表达和植入能力的类囊胚样结构。
Stem Cell Reports. 2019 Sep 10;13(3):485-498. doi: 10.1016/j.stemcr.2019.07.011. Epub 2019 Aug 8.
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Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids.胚胎干细胞向囊胚样体的多轴向自我组织特性。
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仅由干细胞生成的类囊胚结构。
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Sci Rep. 2016 Aug 17;6:31623. doi: 10.1038/srep31623.
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Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.单细胞表观遗传修饰因子分析鉴定 PRDM14 为哺乳动物胚胎细胞命运的诱导因子。
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