Suppr超能文献

束支特异性靶向用于选择性周围神经刺激。

Fascicle specific targeting for selective peripheral nerve stimulation.

机构信息

Nerves Incorporated, Dallas TX, United States of America.

出版信息

J Neural Eng. 2019 Nov 11;16(6):066040. doi: 10.1088/1741-2552/ab4370.

Abstract

OBJECTIVE

Electrical stimulation is a blunt tool for evoking neural activity. Neurons are naturally activated asynchronously and non-uniformly, whereas stimulation drives simultaneous activity within a population of cells. These differences in activation pattern can result in unintended side effects, including muddled sensory percepts and undesirable muscle contractions. These effects can be mitigated by the placement of electrodes in close approximation to nerve fibers and careful selection of the neural interface's location. This work describes the benefits of placing electrodes within specific fascicles of peripheral nerve to form selective neural interfaces for bidirectional neuroprosthetic devices.

APPROACH

Chronic electrodes were targeted to individual fascicles of the ulnar and median nerves in the forearm of four human subjects. During the surgical implant procedure, fascicles were dissected from each nerve, and functional testing was used to identify the relative composition of sensory and motor fibers within each. FAST-LIFE arrays, composed of longitudinal intrafascicular arrays and fascicular cuff electrodes, were implanted in each fascicle. The location, quality, and stimulation parameters associated with sensations evoked by electrical stimulation on these electrodes were characterized throughout the 90-180 d implant period.

MAIN RESULTS

FAST-LIFE arrays enable selective and chronic electrical stimulation of individual peripheral nerve fascicles. The quality of sensations evoked by stimulation in each fascicle is predictable and distinct; subjects reported tactile and cutaneous sensations during stimulation of sensory fascicles and deeper proprioceptive sensations during stimulation of motor fascicles. Stimulation thresholds and strength-duration time constants were typically higher within sensory fascicles.

SIGNIFICANCE

Highly selective, stable neural interfaces can be created by placing electrodes within and around single fascicles of peripheral nerves. This method enables targeting electrodes to nerve fibers that innervate a specific body region or have specific functions. Fascicle-specific interfacing techniques have broad potential to maximize the therapeutic effects of electrical stimulation in many neuromodulation applications. (Clinical Trial ID NCT02994160.).

摘要

目的

电刺激是一种用于引发神经活动的钝性工具。神经元自然地异步且不均匀地被激活,而刺激则驱动细胞群体的同步活动。这些激活模式的差异可能导致意想不到的副作用,包括混乱的感觉知觉和不希望的肌肉收缩。通过将电极放置在接近神经纤维的位置并仔细选择神经接口的位置,可以减轻这些影响。这项工作描述了将电极放置在周围神经的特定束内以形成用于双向神经假体装置的选择性神经接口的好处。

方法

慢性电极被靶向到四个人类受试者前臂的尺神经和正中神经的各个束内。在手术植入过程中,从每个神经中解剖出束,并使用功能测试来识别每个神经束内感觉和运动纤维的相对组成。FAST-LIFE 阵列由纵向束内阵列和束套电极组成,被植入每个束内。在 90-180 天的植入期间,对这些电极上的电刺激引起的感觉的位置、质量和刺激参数进行了表征。

主要结果

FAST-LIFE 阵列能够选择性地和慢性地刺激单个周围神经束。刺激每个束内引起的感觉质量是可预测且独特的;在刺激感觉束时,受试者报告触觉和皮肤感觉,而在刺激运动束时,报告更深的本体感觉。刺激阈值和强度-持续时间时间常数通常在感觉束内较高。

意义

通过将电极放置在周围神经的单个束内和周围,可以创建高度选择性、稳定的神经接口。这种方法可以将电极靶向到支配特定身体区域或具有特定功能的神经纤维。束内接口技术具有广泛的潜力,可以在许多神经调节应用中最大限度地发挥电刺激的治疗效果。(临床试验 ID:NCT02994160)。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验