Institute of Inorganic Chemistry, Faculty of Chemistry and Mineralogy, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany.
Bayer AG, Aprather Weg 18A, 42113 Wuppertal, Germany.
Molecules. 2019 Sep 10;24(18):3288. doi: 10.3390/molecules24183288.
The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba--dodecaborane(12), as well as α-d-galactopyranose for increased hydrophilicity, with a novel boron-rich tris--carboranyl thiol.
肿瘤组织中硼的积累量对于硼中子俘获治疗（BNCT）的成功起着重要作用。在本文中，我们报告了一个模块化系统，该系统结合了易于获得的起始材料，如甘氨酸、1,3,5-三嗪和著名的 9-巯基-1,7-二碳杂-十二硼烷（12），以及增加亲水性的α-D-半乳糖吡喃糖，与一种新型富硼三-碳硼烷硫醇。
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