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电化学生物传感器用于检测肺癌生物标志物:综述。

Electrochemical biosensors for the detection of lung cancer biomarkers: A review.

机构信息

Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.

出版信息

Talanta. 2020 Jan 1;206:120251. doi: 10.1016/j.talanta.2019.120251. Epub 2019 Aug 10.


DOI:10.1016/j.talanta.2019.120251
PMID:31514848
Abstract

Cancer is one of the most widespread challenges and important diseases, which has the highest mortality rate. Lung cancer is the most common type of cancer, so that about 25% of all cancer deaths are related to the lung cancer. The lung cancer is classified as two different types with different treatment methodology: the small cell lung carcinoma and nonsmall cell lung carcinoma are two categories of the lung cancer. Since the lung cancer is often in the latent period in its early stages, therefore, early diagnosis of lung cancer has many challenges. Hence, there is a need for sensitive and reliable tools for preclinical diagnosis of lung cancer. Therefore, many detection methods have been employed for early detection of lung cancer. As lung cancer tumors growth in the body, the cancerous cells release numerous DNA, proteins, and metabolites as special biomarkers of the lung cancer. The levels of these biomarkers show the stages of the lung cancer. Therefore, detection of the biomarkers can be used for screening and clinical diagnosis of the lung cancer. There are numerous biomarkers for the lung cancer such as EGFR, CEA, CYFRA 21-1, ENO1, NSE, CA 19-9, CA 125 and VEGF. Nowadays, electrochemical methods are very attractive and useful in the lung cancer detections. So, in this paper, the recent advances and improvements (2010-2018) in the electrochemical detection of the lung cancer biomarkers have been reviewed.

摘要

癌症是最常见的挑战和重要疾病之一,其死亡率最高。肺癌是最常见的癌症类型,约 25%的癌症死亡与肺癌有关。肺癌分为两种不同类型,治疗方法也不同:小细胞肺癌和非小细胞肺癌是肺癌的两种类型。由于肺癌在早期通常处于潜伏期,因此肺癌的早期诊断存在诸多挑战。因此,需要用于肺癌临床前诊断的敏感可靠的工具。因此,已经采用了许多检测方法来早期发现肺癌。随着肺癌肿瘤在体内生长,癌细胞会释放出许多 DNA、蛋白质和代谢物作为肺癌的特殊生物标志物。这些生物标志物的水平显示了肺癌的阶段。因此,检测生物标志物可用于肺癌的筛查和临床诊断。肺癌有许多生物标志物,如 EGFR、CEA、CYFRA 21-1、ENO1、NSE、CA 19-9、CA 125 和 VEGF。如今,电化学方法在肺癌检测中非常有吸引力和有用。因此,本文综述了 2010 年至 2018 年期间电化学检测肺癌生物标志物的最新进展和改进。

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