Bainbridge Wilma A, Berron David, Schütze Hartmut, Cardenas-Blanco Arturo, Metzger Coraline, Dobisch Laura, Bittner Daniel, Glanz Wenzel, Spottke Annika, Rudolph Janna, Brosseron Frederic, Buerger Katharina, Janowitz Daniel, Fliessbach Klaus, Heneka Michael, Laske Christoph, Buchmann Martina, Peters Oliver, Diesing Dominik, Li Siyao, Priller Josef, Spruth Eike Jakob, Altenstein Slawek, Schneider Anja, Kofler Barbara, Teipel Stefan, Kilimann Ingo, Wiltfang Jens, Bartels Claudia, Wolfsgruber Steffen, Wagner Michael, Jessen Frank, Baker Chris I, Düzel Emrah
Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Alzheimers Dement (Amst). 2019 Sep 5;11:610-618. doi: 10.1016/j.dadm.2019.07.005. eCollection 2019 Dec.
Impaired long-term memory is a defining feature of mild cognitive impairment (MCI). We tested whether this impairment is item specific, limited to some memoranda, whereas some remain consistently memorable.
We conducted item-based analyses of long-term visual recognition memory. Three hundred ninety-four participants (healthy controls, subjective cognitive decline [SCD], and MCI) in the multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) were tested with images from a pool of 835 photographs.
We observed consistent memorability for images in healthy controls, SCD, and MCI, predictable by a neural network trained on another healthy sample. Looking at memorability differences between groups, we identified images that could successfully categorize group membership with higher success and a substantial image reduction than the original image set.
Individuals with SCD and MCI show consistent memorability for specific items, while other items show significant diagnosticity. Certain stimulus features could optimize diagnostic assessment, while others could support memory.
长期记忆受损是轻度认知障碍（MCI）的一个决定性特征。我们测试了这种损伤是否是特定于项目的，仅限于某些记忆内容，而有些则始终易于记忆。
我们对长期视觉识别记忆进行了基于项目的分析。在多中心的德国神经退行性疾病中心纵向认知障碍与痴呆研究（DELCODE）中，对394名参与者（健康对照、主观认知下降[SCD]和MCI）使用来自835张照片库的图像进行了测试。
我们在健康对照、SCD和MCI中观察到图像的一致可记忆性，这可以由在另一个健康样本上训练的神经网络预测。观察组间的可记忆性差异，我们识别出可以成功将组成员分类的图像，其成功率更高，且图像数量比原始图像集大幅减少。
SCD和MCI个体对特定项目表现出一致的可记忆性，而其他项目则具有显著的诊断性。某些刺激特征可以优化诊断评估，而其他特征则可以支持记忆。
