Department of Epidemiology and Health Statistics, School of Public Health and Management, Ningxia Medical University, 1160 South Shengli Street, Yinchuan, Ningxia Hui Autonomous Region, China.
Department of Epidemiology and Health Statistics, School of Public Health and Management, Ningxia Medical University, 1160 South Shengli Street, Yinchuan, Ningxia Hui Autonomous Region, China.
J Affect Disord. 2020 Jan 1;260:272-280. doi: 10.1016/j.jad.2019.07.087. Epub 2019 Jul 30.
Many researchers have concluded that early parental loss during childhood is a risk factor for depression in late life of adults; however others didn't find any association. The objective of this systematic review is to assess whether this association exists or not by conducting a meta-analysis of published studies.
Nine published case-controlled studies were chosen through literature searches in PUBMED, and LIBRARY GENESIS. Newcastle-Ottawa Scale (NOS) have been used to assess the quality of studies included. Thereafter, data were extracted from each study and analysed using ProMeta.
Nine case-controlled studies (representing n = 2784, cases=716 and controls=2068) were included in meta-analysis. The overall random effects model results of parental loss [OR = 2.18, 95% CI, 1.63-2.90, p < 0.00; I = 15.79%, df = 8, p = 0.302], parental death [OR = 1.76, 95% CI, 1.13-2.73, p = 0.012; I = 0.00%, df = 3, p = 0.600] and parental separation [OR = 3.14, 95% CI, 1.92-5.15, p < 0.001; I = 0.00%, df = 2, p = 0.675] showed a strong positive effect on developing depression in adults. Egger's linear regression test [t = 0.14, p = 0.895] and Begg and Mazumdar's rank correlation test [z = 0.63, p = 0.532] confirmed absence of publication bias of studies included in this meta-analysis.
This systematic review was limited by a small number of case-controlled studies included in meta-analysis due to the differences in methodological designs of studies.
The study concluded that parental loss, parental death, and parental separation before age 18 are risk factors of depression in adulthood.
许多研究人员得出结论，儿童期早期父母丧失是成年人晚年抑郁的一个风险因素；然而，也有其他人没有发现任何关联。本系统评价的目的是通过对已发表的研究进行荟萃分析来评估这种关联是否存在。
通过在 PUBMED 和 LIBRARY GENESIS 中进行文献检索，选择了 9 项已发表的病例对照研究。采用纽卡斯尔-渥太华量表（NOS）评估纳入研究的质量。然后，从每项研究中提取数据，并使用 ProMeta 进行分析。
纳入荟萃分析的 9 项病例对照研究（代表 n=2784 例，病例=716 例，对照=2068 例）。父母丧失[OR=2.18，95%CI，1.63-2.90，p<0.00；I=15.79%，df=8，p=0.302]、父母死亡[OR=1.76，95%CI，1.13-2.73，p=0.012；I=0.00%，df=3，p=0.600]和父母分离[OR=3.14，95%CI，1.92-5.15，p<0.001；I=0.00%，df=2，p=0.675]对成年人患抑郁症有很强的正向影响。Egger 线性回归检验[t=0.14，p=0.895]和 Begg 和 Mazumdar 的等级相关检验[z=0.63，p=0.532]证实了纳入本荟萃分析的研究不存在发表偏倚。
由于研究设计方法的差异，本系统评价受到纳入荟萃分析的病例对照研究数量较少的限制。
研究得出结论，18 岁前父母丧失、父母死亡和父母分离是成年期抑郁的危险因素。
