Azizi Esfandiar, Zavaran Hosseini Ahmad, Soudi Sara, Noorbala Ahmad Ali
Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Psychosomatic Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Allergy Asthma Immunol. 2019 Jun 8;18(3):262-268. doi: 10.18502/ijaai.v18i3.1119.
A growing body of evidence suggests the existence of abnormalities in the immune system of schizophrenic patients. The current study examined serum levels of interleukin (IL) -1β, IL-6, IL-2,interferon(IFN) -γ, and tumor necrosis factor(TNF)-α in schizophrenic patients before and after treatment with risperidone and correlated levels of these cytokines with symptomatology. The study group consisted of 24 schizophrenic patients as defined by Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV) criteria and 24 healthy controls. Serum cytokine levels were examined using enzyme-linked immunosorbent assay (ELISA). Schizophrenic symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS) questionnaire. The serum levels of TNF-α, IL-1β and IL-6 were significantly higher in participants before treatment compared with the healthy controls and after treatment (p<0.001). IFN-γ and IL-2 levels were significantly lower in participants after treatment compared with before treatment and the healthy controls (p<0.001). Except for IL-6 (p<0.05), there was no significant difference in the levels of TNF-α and IL-1β between the patients receiving treatment and the healthy subjects. Moreover, there was no significant difference in levels of IFN-γ and IL-2 between patients before treatment and the healthy subjects. There were no significant correlations between the concentration of cytokines studied and the PANSS. Positive intercorrelations between the production of IFN-γ and IL-2 were detected for sums of all groups(r=0.33, p=0.005). Clinical improvement of treated patients was associated with a reduction in the studied cytokines. It seems that changes in the cytokines level may play a significant role in the psychopathology of these patients.
越来越多的证据表明，精神分裂症患者的免疫系统存在异常。本研究检测了精神分裂症患者在使用利培酮治疗前后血清白细胞介素（IL）-1β、IL-6、IL-2、干扰素（IFN）-γ和肿瘤坏死因子（TNF）-α的水平，并将这些细胞因子的水平与症状学进行关联分析。研究组由24例符合《精神障碍诊断与统计手册》第4版（DSM-IV）标准的精神分裂症患者和24名健康对照者组成。采用酶联免疫吸附测定（ELISA）法检测血清细胞因子水平。用阳性和阴性症状量表（PANSS）问卷评估精神分裂症的症状。与健康对照者相比，治疗前参与者的TNF-α、IL-1β和IL-6血清水平显著升高，治疗后也显著升高（p<0.001）。与治疗前和健康对照者相比，治疗后参与者的IFN-γ和IL-2水平显著降低（p<0.001）。除IL-6外（p<0.05），接受治疗的患者与健康受试者之间的TNF-α和IL-1β水平无显著差异。此外，治疗前患者与健康受试者之间的IFN-γ和IL-2水平无显著差异。所研究的细胞因子浓度与PANSS之间无显著相关性。在所有组的总和中检测到IFN-γ和IL-2产生之间存在正相关（r=0.33，p=0.005）。治疗患者的临床改善与所研究的细胞因子减少有关。细胞因子水平的变化似乎在这些患者的精神病理学中起重要作用。
