van Dam I, Wijn P, de Boo T, Hopman J, van Oort A, Fast J, Heringa A, van der Werf T, Daniëls O
Interuniversity Cardiology Institute, The Netherlands/University Hospital Nijmegen, Utrecht.
J Clin Ultrasound. 1988 Jul-Aug;16(6):375-81. doi: 10.1002/jcu.1870160603.
The effects of aging on cardiac blood flow velocities are important as a description of the natural history of the aging process and as a reference for evaluation of the aging cardiovascular system. We therefore studied these effects in 215 healthy volunteers, 120 males and 95 females, between 1 and 65 years old. Pulsed Doppler signals were recorded proximal and distal to the mitral (M) and tricuspid (T) valves, in the left ventricular outflow tract (LVOT), in the ascending aorta (AAO), in the right ventricular outflow tract (RVOT), and in the pulmonary artery (PA). Systolic (S) flow velocity patterns consist mainly of one peak. Diastolic blood flow velocity is characterized by two peaks: one due to early filling (E) of the ventricle and a second as a result of atrial contraction (A). All peaks are characterized by the maximum of the median velocity curve (Vmax). With age increasing from 1 to 65 years, VmaxS decreases in the AAO (40%) and PA (10%), VmaxE decreases on both sides of the M valve (proximal-50%; distal-30%), and the T valve (proximal-20%; distal-30%). However, with increasing age VmaxS increases in the LVOT (25%), and VmaxA increases on both sides of the M valve (proximal-20%; distal-50%) and proximal to the T valve (30%). VmaxS in the RVOT and VmaxA distal to the T valve did not show a relation with age. These observations demonstrate that in a normal population Vmax in the heart and great vessels is age dependent at most sites.(ABSTRACT TRUNCATED AT 250 WORDS)
衰老对心脏血流速度的影响，对于描述衰老过程的自然史以及评估衰老的心血管系统具有重要意义。因此，我们对215名1至65岁的健康志愿者（120名男性和95名女性）进行了这些影响的研究。在二尖瓣（M）和三尖瓣（T）瓣膜近端和远端、左心室流出道（LVOT）、升主动脉（AAO）、右心室流出道（RVOT）以及肺动脉（PA）记录脉冲多普勒信号。收缩期（S）血流速度模式主要由一个峰值组成。舒张期血流速度的特征是两个峰值：一个是由于心室早期充盈（E），另一个是心房收缩（A）的结果。所有峰值均以中位速度曲线的最大值（Vmax）为特征。随着年龄从1岁增加到65岁，AAO中VmaxS下降（40%），PA中下降（10%），M瓣两侧的VmaxE下降（近端 - 50%；远端 - 30%），T瓣两侧的VmaxE下降（近端 - 20%；远端 - 30%）。然而，随着年龄增加，LVOT中VmaxS增加（25%），M瓣两侧的VmaxA增加（近端 - 20%；远端 - 50%），T瓣近端的VmaxA增加（30%）。RVOT中的VmaxS和T瓣远端的VmaxA与年龄无关。这些观察结果表明，在正常人群中，心脏和大血管中大多数部位的Vmax与年龄相关。（摘要截断于250字）
