Rosa Rafael Borges, Costa Mylla Spirandelli da, Teixeira Samuel Cota, Castro Emilene Ferreira de, Dantas Willyenne Marília, Ferro Eloisa Amália Vieira, Silva Murilo Vieira da
Rodents Animal Facilities Complex, Federal University of Uberlandia, Uberlandia 38400-902, Brazil.
Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia 38405-318, Brazil.
Pathogens. 2022 Mar 17;11(3):369. doi: 10.3390/pathogens11030369.
The appearance and spread of parasitic diseases around the world aroused the interest of the scientific community to discover new animal models for improving the quality and specificity of surveys. is a rodent native to South America, an easy handling model, with satisfactory longevity and reproducibility. is susceptible to toxoplasmosis and can be used as experimental model for the study the pathogenesis, treatment, vertical transmission, and ocular toxoplasmosis. can also be used to study cutaneous and visceral leishmaniasis, as the animals present cutaneous lesions, as well as parasites in the organs. has epidemiological importance in Chagas disease, and since it is a natural host in which rodents show high parasitemia and lethality, they are also effective as a model of congenital transmission. In the study of schistosomiasis, was proven to be a natural host; thus, this rodent is a great model for fibrosis, hepatic granulomatous reaction, and celloma associated with lymphomyeloid tissue (CALT) during infection. In this review, we summarize the leading studies of parasitic diseases that used as a rodent experimental model, describing the main uses and characteristics that led them to be considered an effective model.
寄生虫病在全球的出现和传播引起了科学界的兴趣，促使其探索新的动物模型，以提高调查的质量和特异性。[某种啮齿动物]原产于南美洲，是一种易于操作的模型，具有令人满意的寿命和可重复性。[该啮齿动物]易感染弓形虫病，可作为研究弓形虫病发病机制、治疗、垂直传播和眼部弓形虫病的实验模型。[该啮齿动物]还可用于研究皮肤利什曼病和内脏利什曼病，因为这些动物会出现皮肤病变，且器官中存在寄生虫。[该啮齿动物]在恰加斯病中具有流行病学意义，由于它是一种天然宿主，啮齿动物在其中表现出高寄生虫血症和致死率，因此它们也是先天性传播的有效模型。在血吸虫病研究中，[该啮齿动物]被证明是一种天然宿主；因此，这种啮齿动物是研究感染期间纤维化、肝肉芽肿反应以及与淋巴髓样组织（CALT）相关的细胞瘤的理想模型。在本综述中，我们总结了将[该啮齿动物]用作啮齿动物实验模型的寄生虫病主要研究，描述了使其被视为有效模型的主要用途和特征。
