安大略省肉鸡临床分离株对孵化场使用的抗菌药物的耐药性。
Resistance to antimicrobials used at hatchery level among clinical isolates from Ontario broilers.
作者信息
Kadykalo Stefanie V, Pearl David L, Slavic Durda, McEwen Scott A
机构信息
Department of Population Medicine, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Kadykalo, Pearl, McEwen); Animal Health Laboratory, 419 Gordon Street, Guelph, Ontario N1G 2W1 (Slavic).
出版信息
Can Vet J. 2019 Sep;60(9):945-954.
Antimicrobials are used for prophylactic purposes in some flocks because chicks are susceptible to pathogenic bacterial infection at the hatchery stage. The objectives of this study were to assess temporal changes in resistance to ceftiofur, gentamicin, and spectinomycin in clinical isolates from Ontario broiler chickens between 2008 and 2015, to determine whether stage of production, year and season are predictors of resistance, and whether published data on antimicrobial use help to interpret the temporal patterns in resistance. Logistic regression revealed that stage of production, year, and season were significant predictors of resistance to all 3 antimicrobials. Resistance to ceftiofur fluctuated over time, with a trend towards decreasing resistance between 2013 to 2015; resistance to gentamicin and spectinomycin increased over the study period, with significantly high resistance clusters identified from 2013 to 2015. Comparisons with published hatchery-level antimicrobial use data suggest that these trends may reflect changes in use of ceftiofur and spectinomycin in Ontario.
由于雏鸡在孵化场阶段易受致病性细菌感染，因此在一些鸡群中使用抗菌药物进行预防。本研究的目的是评估2008年至2015年安大略省肉鸡临床分离株对头孢噻呋、庆大霉素和壮观霉素的耐药性随时间的变化，确定生产阶段、年份和季节是否为耐药性的预测因素，以及已发表的抗菌药物使用数据是否有助于解释耐药性的时间模式。逻辑回归显示，生产阶段、年份和季节是所有三种抗菌药物耐药性的显著预测因素。对头孢噻呋的耐药性随时间波动，在2013年至2015年期间有耐药性下降的趋势；在研究期间，对庆大霉素和壮观霉素的耐药性增加，在2013年至2015年期间发现了耐药性显著高的聚集情况。与已发表的孵化场水平抗菌药物使用数据的比较表明，这些趋势可能反映了安大略省头孢噻呋和壮观霉素使用情况的变化。
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