Wang J, Martin J F
1 Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
2 Texas Heart Institute, Houston, TX, USA.
J Dent Res. 2017 Oct;96(11):1229-1237. doi: 10.1177/0022034517719886. Epub 2017 Jul 12.
The evolutionarily conserved Hippo signaling pathway is a vital regulator of organ size that fine-tunes cell proliferation, apoptosis, and differentiation. A number of important studies have revealed critical roles of Hippo signaling and its effectors Yap (Yes-associated protein) and Taz (transcriptional coactivator with PDZ binding motif) in tissue development, homeostasis, and regeneration, as well as in tumorigenesis. In addition, recent studies have shown evidence of crosstalk between the Hippo pathway and other key signaling pathways, such as Wnt signaling, that not only regulates developmental processes but also contributes to disease pathogenesis. In this review, we summarize the major discoveries in the field of Hippo signaling and what has been learned about its regulation and crosstalk with other signaling pathways, with a particular focus on recent findings involving the Hippo-Yap pathway in craniofacial and tooth development. New and exciting studies of the Hippo pathway are anticipated that will significantly improve our understanding of the molecular mechanisms of human craniofacial and tooth development and disease and will ultimately lead to the development of new therapies.
进化上保守的Hippo信号通路是器官大小的重要调节因子，可微调细胞增殖、凋亡和分化。许多重要研究揭示了Hippo信号及其效应分子Yap（Yes相关蛋白）和Taz（含PDZ结合基序的转录共激活因子）在组织发育、稳态和再生以及肿瘤发生中的关键作用。此外，最近的研究表明Hippo通路与其他关键信号通路（如Wnt信号通路）之间存在串扰的证据，Wnt信号通路不仅调节发育过程，还与疾病发病机制有关。在这篇综述中，我们总结了Hippo信号领域的主要发现以及我们对其调节和与其他信号通路串扰的了解，特别关注涉及Hippo-Yap通路在颅面和牙齿发育中的最新发现。预计对Hippo通路的新的激动人心的研究将显著提高我们对人类颅面和牙齿发育及疾病分子机制的理解，并最终导致新疗法的开发。
