抗核抗体阴性患者中抗单链DNA抗体的出现情况。
Occurrence of antibodies to single-stranded DNA in ANA negative patients.
作者信息
Wasicek C A, Maddison P J, Reichlin M
出版信息
Clin Exp Immunol. 1979 Aug;37(2):190-5.
Abstract
Five patients with clinical features of a connective tissue disease most suggestive of systemic lupus erythematosus were found to have a negative ANA by conventional screening at 1/20 dilution on mouse liver. However, significant titres of antibodies to single-stranded DNA were detected using a double antibody radioimmunoassay. Thus, certain patients have antibodies to DNA restricted to single-stranded determinants as detected by radioimmunoassay with single-stranded DNA as antigen and a negative ANA test.
摘要
五名具有结缔组织疾病临床特征且最提示系统性红斑狼疮的患者，在以1/20稀释度对小鼠肝脏进行常规筛查时，抗核抗体（ANA）呈阴性。然而，使用双抗体放射免疫测定法检测到了显著滴度的抗单链DNA抗体。因此，通过以单链DNA为抗原的放射免疫测定法检测，某些患者具有仅限于单链决定簇的DNA抗体，且ANA检测呈阴性。
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