If电流阻断对依Langendorff法分离的新生大鼠心脏的影响。
Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff.
作者信息
Ziyatdinova N I, Kuptsova A M, Faskhutdinov L I, Galieva A M, Zefirov A L, Zefirov T L
机构信息
Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Russia.
Department of Normal Physiology, Kazan Federal Medical University, Kazan, the republic of Tatarstan, Russia.
出版信息
Bull Exp Biol Med. 2019 Aug;167(4):424-427. doi: 10.1007/s10517-019-04541-w. Epub 2019 Sep 16.
The study examined the effects of hyperpolarization-activated funny current (If) on HR and coronary flow in Langendorff-isolated hearts from newborn rats. Blockade of If current with ZD7288 changed the examined cardiac parameters. The blocker in a concentration of 10 M decreased HR by 26.8% (p≤0.05). In concentrations 10, 10, 10, and 10 M ZD7288 produced minor differently directed effects. In a concentration of 10 M, ZD7288 reduced coronary flow in the isolated heart (p≤0.01). In other concentrations, the blocker produced no significant effects on coronary flow.
该研究检测了超极化激活的内向整流钾电流（If）对新生大鼠Langendorff离体心脏心率（HR）和冠脉血流的影响。用ZD7288阻断If电流改变了所检测的心脏参数。浓度为10 μM的该阻滞剂使心率降低了26.8%（p≤0.05）。浓度为10 μM、10 μM、10 μM和10 μM的ZD7288产生了轻微的不同方向的效应。浓度为10 μM时，ZD7288使离体心脏的冠脉血流减少（p≤0.01）。在其他浓度下，该阻滞剂对冠脉血流无显著影响。
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