Bhuta Roma, Nieder Michael, Jubelirer Tracey, Ladas Elena J
Division of Pediatric Hematology-Oncology, Hasbro Children's Hospital, The Warren Alpert Medical School of Brown University, Providence, RI.
Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, University of South Florida College of Medicine, Tampa, FL.
J Natl Cancer Inst Monogr. 2019 Sep 1;2019(54):169-173. doi: 10.1093/jncimonographs/lgz026.
The human microbiome consists of trillions of microbial cells that interact with one another and the human host to play a clinically significant role in health and disease. Gut microbial changes have been identified in cancer pathogenesis, at disease diagnosis, during therapy, and even long after completion of treatment. Alterations in the gut microbiome have been linked to treatment-related toxicity and potential long-term morbidity and mortality in children with cancer. Such alterations are plausible given immune modulation due to disease as well as exposure to cytotoxic chemotherapy, infections, and antibiotics. The following review presents our current scientific understanding on the role of the gut microbiome in pediatric cancer, identifies gaps in knowledge, and suggests future research goals.
人类微生物组由数万亿个微生物细胞组成，这些细胞相互作用，并与人类宿主相互作用，在健康和疾病中发挥着具有临床意义的作用。在癌症发病机制、疾病诊断、治疗期间甚至治疗结束后很长一段时间内，都已发现肠道微生物的变化。肠道微生物组的改变与癌症患儿的治疗相关毒性以及潜在的长期发病率和死亡率有关。鉴于疾病引起的免疫调节以及接触细胞毒性化疗、感染和抗生素，这种改变是合理的。以下综述介绍了我们目前对肠道微生物组在儿科癌症中作用的科学认识，确定了知识空白，并提出了未来的研究目标。
