Geary D F, Thorner P, Baumal R, Major M, Arbus G
Department of Pediatrics, Hospital for Sick Children, Ontario, Canada.
Pediatr Nephrol. 1987 Apr;1(2):140-4. doi: 10.1007/BF00849284.
The effect on renal function and growth of switching from azathioprine to cyclosporin A (CyA) was prospectively evaluated in ten children with persistent renal transplant rejection. Progression of renal insufficiency during CyA therapy was compared with that before using CyA. Prednisone administration decreased after CyA was introduced and although growth retardation persisted, height velocity improved significantly. Renal function stabilized in seven patients treated with CyA for a variable time period, and four of these children remain off dialysis 0.44-1.42 years later. Renal biopsies were obtained in seven children when they were converted from azathioprine to CyA. The response to CyA could not be predicted from renal morphology or clinical features.
对10例持续性肾移植排斥反应患儿，前瞻性评估了从硫唑嘌呤转换为环孢素A（CyA）对肾功能和生长的影响。将CyA治疗期间肾功能不全的进展与使用CyA之前进行了比较。引入CyA后泼尼松的用量减少，尽管生长迟缓仍然存在，但身高增长速度显著改善。7例接受CyA治疗不同时间段的患者肾功能稳定，其中4名儿童在0.44 - 1.42年后不再需要透析。7名儿童从硫唑嘌呤转换为CyA时进行了肾活检。无法根据肾脏形态或临床特征预测对CyA的反应。
