具有抗[具体对象]和耐甲氧西林金黄色葡萄球菌活性的铱钢琴凳配合物：现在是真正跳出框框思考的时候了。 （注：原文中“against and MRSA”中间少了具体针对的对象，以上译文是根据完整合理的逻辑补充后翻译的）
Iridium piano stool complexes with activity against and MRSA: it is past time to truly think outside of the box.
作者信息
DuChane Christine M, Karpin George W, Ehrich Marion, Falkinham Joseph O, Merola Joseph S
机构信息
Virginia Tech Center for Drug Discovery , Blacksburg , VA 24061 , USA . Email:
Department of Chemistry , Virginia Tech , Blacksburg , VA 24061 , USA.
出版信息
Medchemcomm. 2019 May 14;10(8):1391-1398. doi: 10.1039/c9md00140a. eCollection 2019 Aug 1.
Abstract
A new class of piano-stool iridium complexes with 1,2-diaminoethane ligands are shown to be effective and safe antimicrobials with activity against , including various isolates of methicillin-resistant strains (MRSA). Comparison to other piano stool complexes with activity against mycobacteria are made along with a discussion of structure-activity relationships. The structures of one the most active complexes with the ligand -1,2-diaminocyclohexane and one of the least active complexes with the ligand -1,2-diaminocyclohexane are compared and discussed with respect to their drastically different activities. toxicity studies for all of the complexes are described. In addition, a mouse study with one of the complexes, [(pentamethylcyclopentadienyl)(-1,2-diaminocyclohexane)(chloro)iridium]chloride, showed no ill effects on the mice at high doses.
摘要
一类新型的带有1,2 - 二氨基乙烷配体的钢琴凳型铱配合物被证明是有效且安全的抗菌剂，对包括各种耐甲氧西林菌株（MRSA）分离株在内的多种细菌具有活性。文中将其与其他对分枝杆菌有活性的钢琴凳型配合物进行了比较，并讨论了构效关系。比较并讨论了配体为 - 1,2 - 二氨基环己烷的活性最高的一种配合物和活性最低的一种配合物的结构及其截然不同的活性。描述了所有配合物的毒性研究。此外，对其中一种配合物，即氯化[（五甲基环戊二烯基）（ - 1,2 - 二氨基环己烷）（氯）铱]进行的小鼠研究表明，高剂量时对小鼠没有不良影响。
相似文献
1
Iridium piano stool complexes with activity against and MRSA: it is past time to truly think outside of the box.具有抗[具体对象]和耐甲氧西林金黄色葡萄球菌活性的铱钢琴凳配合物：现在是真正跳出框框思考的时候了。 （注：原文中“against and MRSA”中间少了具体针对的对象，以上译文是根据完整合理的逻辑补充后翻译的）
Medchemcomm. 2019 May 14;10(8):1391-1398. doi: 10.1039/c9md00140a. eCollection 2019 Aug 1.
2
Novel and Versatile Imine-N-Heterocyclic Carbene Half-Sandwich Iridium(III) Complexes as Lysosome-Targeted Anticancer Agents.新型多功能亚胺-N-杂环卡宾半夹心型铱(III)配合物作为溶酶体靶向抗癌剂。
Inorg Chem. 2018 Sep 4;57(17):11087-11098. doi: 10.1021/acs.inorgchem.8b01656. Epub 2018 Aug 22.
3
Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties.含（N^N和N^O）键合氯喹类似物配体的五甲基环戊二烯基铑和铱配合物：合成、表征及抗疟性能
Dalton Trans. 2016 Mar 7;45(9):3905-17. doi: 10.1039/c5dt03739e. Epub 2016 Feb 2.
4
Inert cationic iridium(III) complexes with phenanthroline-based ligands: application in antimicrobial inactivation of multidrug-resistant bacterial strains.基于菲咯啉的惰性阳离子铱(III)配合物：在抗多重耐药菌菌株抗菌失活中的应用。
Dalton Trans. 2022 Jun 27;51(25):9653-9663. doi: 10.1039/d2dt00752e.
5
Prevalence and characterization of methicillin-resistant Staphylococcus aureus carrying mecA or mecC and methicillin-susceptible Staphylococcus aureus in dairy sheep farms in central Italy.意大利中部奶绵羊场耐甲氧西林金黄色葡萄球菌（mecA 或 mecC 携带）和甲氧西林敏感金黄色葡萄球菌的流行及特征。
J Dairy Sci. 2017 Oct;100(10):7857-7863. doi: 10.3168/jds.2017-12940. Epub 2017 Aug 2.
6
Chlorido-containing ruthenium(II) and iridium(III) complexes as antimicrobial agents.含氯的钌(II)和铱(III)配合物作为抗菌剂。
Dalton Trans. 2013 Apr 7;42(13):4686-94. doi: 10.1039/c3dt32775b.
7
Simultaneous Ultrasensitive Detection and Elimination of Drug-Resistant Bacteria by Cyclometalated Iridium(III) Complexes.通过金属环配合铱(III)配合物同时进行超灵敏检测和耐药菌消除。
ACS Appl Mater Interfaces. 2020 Aug 12;12(32):35967-35976. doi: 10.1021/acsami.0c11161. Epub 2020 Jul 28.
8
In vitro and in vivo activities of echinomycin against clinical isolates of Staphylococcus aureus.棘霉素对金黄色葡萄球菌临床分离株的体外和体内活性
J Antimicrob Chemother. 2008 Jan;61(1):163-8. doi: 10.1093/jac/dkm421. Epub 2007 Oct 29.
9
Antimicrobial Properties of Tris(homoleptic) Ruthenium(II) 2-Pyridyl-1,2,3-triazole "Click" Complexes against Pathogenic Bacteria, Including Methicillin-Resistant Staphylococcus aureus (MRSA).三（均配）钌（II）2-吡啶基-1,2,3-三唑“点击”配合物对包括耐甲氧西林金黄色葡萄球菌（MRSA）在内的致病细菌的抗菌特性
Inorg Chem. 2016 Oct 3;55(19):9767-9777. doi: 10.1021/acs.inorgchem.6b01574. Epub 2016 Sep 22.
10
Similarities and differences in d low-spin ruthenium, rhodium and iridium half-sandwich complexes: synthesis, structure, cytotoxicity and interaction with biological targets.低自旋钌、铑和铱半夹心配合物的相似性和差异性：合成、结构、细胞毒性及与生物靶标的相互作用。
J Biol Inorg Chem. 2019 Jun;24(4):591-606. doi: 10.1007/s00775-019-01665-2. Epub 2019 May 21.
引用本文的文献
1
Effect of Ligand Substituents on Spectroscopic and Catalytic Properties of Water-Compatible Cp*Ir-(pyridinylmethyl)sulfonamide-Based Transfer Hydrogenation Catalysts.配体取代基对水相容性Cp*Ir-(吡啶基甲基)磺酰胺基转移氢化催化剂的光谱和催化性能的影响
Inorg Chem. 2024 Feb 26;63(8):3815-3823. doi: 10.1021/acs.inorgchem.3c04040. Epub 2024 Feb 11.
2
Computer-Aided Drug Design and Synthesis of Rhenium Clotrimazole Antimicrobial Agents.铼克霉唑抗菌剂的计算机辅助药物设计与合成
Antibiotics (Basel). 2023 Mar 20;12(3):619. doi: 10.3390/antibiotics12030619.
3
Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity.有机金属抗菌药物及具有抗菌活性的金属基材料简述
RSC Chem Biol. 2021 Jan 26;2(2):368-386. doi: 10.1039/d0cb00218f. eCollection 2021 Apr 1.
4
Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2.贵金属有机金属配合物对 SARS-CoV-2 显示抗病毒活性。
Viruses. 2021 May 25;13(6):980. doi: 10.3390/v13060980.
5
Metal Complexes, an Untapped Source of Antibiotic Potential?金属配合物，抗生素潜力的未开发来源？
Antibiotics (Basel). 2020 Feb 18;9(2):90. doi: 10.3390/antibiotics9020090.
6
Octametallic Cluster of Cp*Ir(glycinato) Cations.Cp*Ir（甘氨酸根）阳离子的八金属簇合物。
ACS Omega. 2019 Dec 11;4(26):22126-22132. doi: 10.1021/acsomega.9b03267. eCollection 2019 Dec 24.
本文引用的文献
1
Changing antibiotic resistance patterns for Staphylococcus aureus surgical site infections.金黄色葡萄球菌手术部位感染的抗生素耐药模式变化。
Infect Control Hosp Epidemiol. 2019 Apr;40(4):486-487. doi: 10.1017/ice.2019.4. Epub 2019 Feb 20.
2
Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.耐甲氧西林金黄色葡萄球菌：基础与临床研究概述。
Nat Rev Microbiol. 2019 Apr;17(4):203-218. doi: 10.1038/s41579-018-0147-4.
3
Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant .社区获得性耐甲氧西林. 克隆传播过程中毒力和耐药性的连续演变
Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1745-1754. doi: 10.1073/pnas.1814265116. Epub 2019 Jan 11.
4
Antibiotic resistance: a rundown of a global crisis.抗生素耐药性：全球危机概览
Infect Drug Resist. 2018 Oct 10;11:1645-1658. doi: 10.2147/IDR.S173867. eCollection 2018.
5
Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity.具有强效抗菌活性的双胍铱(III)配合物。
J Med Chem. 2018 Aug 23;61(16):7330-7344. doi: 10.1021/acs.jmedchem.8b00906. Epub 2018 Aug 2.
6
Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance.用于对抗抗菌耐药性的药物磺胺多辛的有机金属共轭物
Chemistry. 2018 Jul 17;24(40):10078-10090. doi: 10.1002/chem.201801090. Epub 2018 Jun 13.
7
Range Expansion and the Origin of USA300 North American Epidemic Methicillin-Resistant .耐药金黄色葡萄球菌 USA300 北美流行株的地域扩张与起源
mBio. 2018 Jan 2;9(1):e02016-17. doi: 10.1128/mBio.02016-17.
8
Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance.重症监护病房中的抗菌药物耐药性和抗生素管理计划：在抗耐药斗争中的坚持和持续努力。ESICM/ESCMID/WAAAR 多药耐药圆桌会议立场声明。
Intensive Care Med. 2018 Feb;44(2):189-196. doi: 10.1007/s00134-017-5036-1. Epub 2017 Dec 29.
9
The Cambridge Structural Database.剑桥结构数据库。
Acta Crystallogr B Struct Sci Cryst Eng Mater. 2016 Apr;72(Pt 2):171-9. doi: 10.1107/S2052520616003954. Epub 2016 Apr 1.
10
Antimicrobial resistance in the 21st century.21世纪的抗菌药物耐药性。
Future Microbiol. 2015;10(3):297-8. doi: 10.2217/fmb.15.24.
Zotero 插件