• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

中国环状 RNA 作为肺癌潜在诊断和预后生物标志物的研究进展。

Potential Diagnostic and Prognostic Biomarkers of Circular RNAs for Lung Cancer in China.

机构信息

Department of Respiratory and Critical Care Medicine, West China Medical School/West China Hospital, Sichuan University, Chengdu, China.

West China Medical School, Sichuan University, Chengdu, China.

出版信息

Biomed Res Int. 2019 Aug 25;2019:8023541. doi: 10.1155/2019/8023541. eCollection 2019.

DOI:10.1155/2019/8023541
PMID:31534962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6732606/
Abstract

Emerging evidence demonstrated that circular RNAs (circRNAs) were dysregulated in lung cancer, indicating that circRNAs might serve as novel diagnostic and prognostic biomarkers for lung cancer. However, the clinical value of circRNAs on lung cancer remains unclear. This study aimed to evaluate the efficiency of circRNAs in the diagnosis and prognosis for lung cancer in China. 2122 Chinese individuals were enrolled in this investigation for assessment of diagnostic value and examination of prognostic analysis. In the diagnostic analysis, the pooled sensitivity, specificity, PLR, NLR, DOR, and AUC of the sROC curve with their 95% CIs were 0.80 (95%CI: 0.74-0.84), 0.80 (95%CI: 0.73-0.86), 3.97 (95%CI: 2.80-5.62) and 0.26 (95%CI: 0.19-0.34), 15.51 (95%CI: 8.76-24.47), and 0.85 (95%CI: 0.82-0.88), respectively. As for the prognostic power of circRNAs, lung cancer patients with higher expression levels of circRNAs tend to possess lower overall survival with the overall pooled HR (1.70, 95%CI: 1.26-2.29). Furthermore, in stratified analysis, upregulated and downregulated circRNAs were manifested to exert significant effects on prognosis with HR values of 2.17 (95%CI: 1.74-2.72) and 0.52 (95%CI: 0.34-0.80). This study validates that circRNAs are promising diagnostic and predictive biomarkers for lung cancer patients in China.

摘要

越来越多的证据表明，环状 RNA（circRNA）在肺癌中失调，表明 circRNA 可能作为肺癌的新型诊断和预后生物标志物。然而，circRNA 对肺癌的临床价值尚不清楚。本研究旨在评估 circRNA 在中国人群中对肺癌的诊断和预后价值。共有 2122 名中国人参与了本研究，用于评估诊断价值和预后分析。在诊断分析中，汇总敏感性、特异性、PLR、NLR、DOR 和 sROC 曲线的 AUC（95%CI）分别为 0.80（95%CI：0.74-0.84）、0.80（95%CI：0.73-0.86）、3.97（95%CI：2.80-5.62）和 0.26（95%CI：0.19-0.34）、15.51（95%CI：8.76-24.47）和 0.85（95%CI：0.82-0.88）。至于 circRNA 的预后能力，circRNA 表达水平较高的肺癌患者总生存率较低，总合并 HR（1.70，95%CI：1.26-2.29）。此外，在分层分析中，上调和下调的 circRNA 对预后均有显著影响，HR 值分别为 2.17（95%CI：1.74-2.72）和 0.52（95%CI：0.34-0.80）。本研究验证了 circRNA 是中国肺癌患者有前途的诊断和预测生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/ccb3c652e516/BMRI2019-8023541.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/1903974c668b/BMRI2019-8023541.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/efb5a4f07288/BMRI2019-8023541.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/a605617ce1ae/BMRI2019-8023541.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/0912f970114c/BMRI2019-8023541.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/4dc3354d2fcf/BMRI2019-8023541.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/ccda1cfc587f/BMRI2019-8023541.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/0fcb0afffc24/BMRI2019-8023541.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/ccb3c652e516/BMRI2019-8023541.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/1903974c668b/BMRI2019-8023541.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/efb5a4f07288/BMRI2019-8023541.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/a605617ce1ae/BMRI2019-8023541.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/0912f970114c/BMRI2019-8023541.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/4dc3354d2fcf/BMRI2019-8023541.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/ccda1cfc587f/BMRI2019-8023541.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/0fcb0afffc24/BMRI2019-8023541.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/6732606/ccb3c652e516/BMRI2019-8023541.008.jpg

相似文献

1
Potential Diagnostic and Prognostic Biomarkers of Circular RNAs for Lung Cancer in China.中国环状 RNA 作为肺癌潜在诊断和预后生物标志物的研究进展。
Biomed Res Int. 2019 Aug 25;2019:8023541. doi: 10.1155/2019/8023541. eCollection 2019.
2
Diagnostic and prognostic values of circular RNAs for lung cancer: a meta-analysis.环状 RNA 对肺癌的诊断和预后价值：一项荟萃分析。
Postgrad Med J. 2021 May;97(1147):286-293. doi: 10.1136/postgradmedj-2019-137178. Epub 2020 Jun 9.
3
Systematic Review and Meta-Analysis of the Utility of Circular RNAs as Biomarkers of Hepatocellular Carcinoma.系统评价和荟萃分析环状 RNA 作为肝细胞癌生物标志物的效用。
Can J Gastroenterol Hepatol. 2019 May 2;2019:1684039. doi: 10.1155/2019/1684039. eCollection 2019.
4
Identification of Three Circular RNA Cargoes in Serum Exosomes as Diagnostic Biomarkers of Non-Small-Cell Lung Cancer in the Chinese Population.鉴定中国人血清外泌体中的三种环状 RNA cargos 作为非小细胞肺癌的诊断生物标志物。
J Mol Diagn. 2020 Aug;22(8):1096-1108. doi: 10.1016/j.jmoldx.2020.05.011. Epub 2020 Jun 12.
5
Prognostic and diagnostic significance of circRNAs expression in lung cancer.环状 RNA 表达在肺癌中的预后和诊断意义。
J Cell Physiol. 2019 Aug;234(10):18459-18465. doi: 10.1002/jcp.28481. Epub 2019 Mar 20.
6
Diagnostic value of circular RNAs in colorectal cancer: A systematic review and meta-analysis.环状 RNA 在结直肠癌诊断中的价值：系统评价和荟萃分析。
Pathol Res Pract. 2019 Dec;215(12):152680. doi: 10.1016/j.prp.2019.152680. Epub 2019 Oct 3.
7
The predictive value of circular RNAs in the diagnosis, prognosis and clinicopathological features of thyroid cancer: A systematic review and meta-analysis.环状 RNA 对甲状腺癌诊断、预后和临床病理特征的预测价值：系统评价和荟萃分析。
Pathol Res Pract. 2022 Aug;236:153871. doi: 10.1016/j.prp.2022.153871. Epub 2022 Apr 2.
8
A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma.双环状 RNA 特征作为肺腺癌的非侵入性诊断生物标志物。
J Transl Med. 2019 Feb 18;17(1):50. doi: 10.1186/s12967-019-1800-z.
9
CircRNAs as promising biomarker in diagnostic and prognostic of lung cancer: An updated meta-analysis.环状 RNA 作为肺癌诊断和预后的有前途的生物标志物：一项更新的荟萃分析。
Genomics. 2021 Jan;113(1 Pt 1):387-397. doi: 10.1016/j.ygeno.2020.12.013. Epub 2020 Dec 14.
10
The role of circular RNAs (circRNAs) as a prognostic factor in lung cancer: a meta-analysis.环状 RNA（circRNAs）作为肺癌预后因素的作用：一项荟萃分析。
BMC Cancer. 2024 Aug 9;24(1):988. doi: 10.1186/s12885-024-12704-w.

引用本文的文献

1
The role of circular RNAs (circRNAs) as a prognostic factor in lung cancer: a meta-analysis.环状 RNA（circRNAs）作为肺癌预后因素的作用：一项荟萃分析。
BMC Cancer. 2024 Aug 9;24(1):988. doi: 10.1186/s12885-024-12704-w.
2
Circulating noncoding RNAs: promising biomarkers in liquid biopsy for the diagnosis, prognosis, and therapy of NSCLC.循环非编码RNA：液体活检中用于非小细胞肺癌诊断、预后和治疗的有前景的生物标志物。
Discov Oncol. 2023 Aug 1;14(1):142. doi: 10.1007/s12672-023-00686-3.
3
The diagnostic significance of blood-derived circRNAs in NSCLC: Systematic review and meta-analysis.

本文引用的文献

1
Implementation planning for lung cancer screening in China.中国肺癌筛查的实施规划。
Precis Clin Med. 2019 Mar;2(1):13-44. doi: 10.1093/pcmedi/pbz002. Epub 2019 Mar 14.
2
The Landscape of Circular RNA in Cancer.环状 RNA 在癌症中的研究进展
Cell. 2019 Feb 7;176(4):869-881.e13. doi: 10.1016/j.cell.2018.12.021.
3
Circular RNA PVT1 acts as a competing endogenous RNA for miR-497 in promoting non-small cell lung cancer progression.环状 RNA PVT1 作为竞争性内源性 RNA 促进 miR-497 促进非小细胞肺癌进展。
血液来源的环状RNA在非小细胞肺癌中的诊断意义：系统评价与荟萃分析
Front Oncol. 2022 Oct 24;12:987704. doi: 10.3389/fonc.2022.987704. eCollection 2022.
4
Circ_SATB2 knockdown inhibits the tumorigenesis of non-small cell lung cancer via miR-760/KIF2A axis.Circ_SATB2 敲低通过 miR-760/KIF2A 轴抑制非小细胞肺癌的肿瘤发生。
Histol Histopathol. 2023 Apr;38(4):431-441. doi: 10.14670/HH-18-530. Epub 2022 Oct 5.
5
Research progress regarding long-chain non-coding RNA in lung cancer: a narrative review.肺癌中长链非编码RNA的研究进展：一篇叙述性综述。
J Thorac Dis. 2022 Aug;14(8):3016-3029. doi: 10.21037/jtd-22-897.
6
Identification of Three Potential circRNA Biomarkers of Polycystic Ovary Syndrome by Bioinformatics Analysis and Validation.通过生物信息学分析和验证鉴定多囊卵巢综合征的三种潜在环状RNA生物标志物
Int J Gen Med. 2021 Sep 22;14:5959-5968. doi: 10.2147/IJGM.S324126. eCollection 2021.
7
Identification of a methylomics-associated nomogram for predicting overall survival of stage I-II lung adenocarcinoma.鉴定一个甲基组学相关的列线图，用于预测 I-II 期肺腺癌的总生存期。
Sci Rep. 2021 May 11;11(1):9938. doi: 10.1038/s41598-021-89429-4.
8
CircFNDC3B sequestrates miR-937-5p to derepress TIMP3 and inhibit colorectal cancer progression.环状 FNDC3B 可将 miR-937-5p 隔离，解除 TIMP3 的抑制作用，并抑制结直肠癌细胞的进展。
Mol Oncol. 2020 Nov;14(11):2960-2984. doi: 10.1002/1878-0261.12796. Epub 2020 Sep 19.
9
circ_0007385 served as competing endogenous RNA for miR-519d-3p to suppress malignant behaviors and cisplatin resistance of non-small cell lung cancer cells.circ_0007385 作为竞争性内源性 RNA，与 miR-519d-3p 结合，抑制非小细胞肺癌细胞的恶性行为和顺铂耐药性。
Thorac Cancer. 2020 Aug;11(8):2196-2208. doi: 10.1111/1759-7714.13527. Epub 2020 Jun 29.
Biomed Pharmacother. 2019 Mar;111:244-250. doi: 10.1016/j.biopha.2018.12.007. Epub 2018 Dec 24.
4
Circular RNA ciRS-7 correlates with advance disease and poor prognosis, and its down-regulation inhibits cells proliferation while induces cells apoptosis in non-small cell lung cancer.环状 RNA ciRS-7 与疾病进展和预后不良相关，其下调抑制非小细胞肺癌细胞增殖，同时诱导细胞凋亡。
Eur Rev Med Pharmacol Sci. 2018 Dec;22(24):8712-8721. doi: 10.26355/eurrev_201812_16636.
5
CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non-small cell lung cancer by regulating Galectin-1-AKT/ERK1/2 signaling.环状 RNA 成纤维细胞生长因子受体 3 通过调节半乳糖凝集素-1-AKT/ERK1/2 信号通路促进非小细胞肺癌的肿瘤进展。
J Cell Physiol. 2019 Jul;234(7):11256-11264. doi: 10.1002/jcp.27783. Epub 2018 Nov 22.
6
Overexpression of circ-0067934 is associated with increased cellular proliferation and the prognosis of non-small cell lung cancer.circ-0067934的过表达与非小细胞肺癌细胞增殖增加及预后相关。
Oncol Lett. 2018 Nov;16(5):5551-5556. doi: 10.3892/ol.2018.9357. Epub 2018 Aug 23.
7
Hsa_circ_0003998 promotes cell proliferation and invasion by targeting miR-326 in non-small cell lung cancer.Hsa_circ_0003998通过靶向非小细胞肺癌中的miR-326促进细胞增殖和侵袭。
Onco Targets Ther. 2018 Sep 7;11:5569-5577. doi: 10.2147/OTT.S174750. eCollection 2018.
8
A novel circular RNA hsa_circ_0020123 exerts oncogenic properties through suppression of miR-144 in non-small cell lung cancer.一种新型环状RNA hsa_circ_0020123通过抑制非小细胞肺癌中的miR-144发挥致癌特性。
Am J Cancer Res. 2018 Aug 1;8(8):1387-1402. eCollection 2018.
9
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
10
CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression.环状 RNA hsa_circ_100395 通过调控 miR-1228/TCF21 通路抑制肺癌进展。
Cell Cycle. 2018;17(16):2080-2090. doi: 10.1080/15384101.2018.1515553. Epub 2018 Sep 13.