PERITOX-Périnatalité et Risques Toxiques-UMR_I 01, Centre Universitaire de Recherche en Santé, CURS-UPJV, University of Picardy Jules Verne, CEDEX 1, 80054 Amiens, France.
Laboratoire de la Barrière Hémato-Encéphalique (LBHE), UR 2465, University of Artois, 62300 Lens, France.
Int J Mol Sci. 2023 Mar 24;24(7):6147. doi: 10.3390/ijms24076147.
Accumulating evidence indicates that chronic exposure to a low level of pesticides found in diet affects the human gut-microbiota-blood-brain barrier (BBB) axis. This axis describes the physiological and bidirectional connection between the microbiota, the intestinal barrier (IB), and the BBB. Preclinical observations reported a gut microbial alteration induced by pesticides, also known as dysbiosis, a condition associated not only with gastrointestinal disorders but also with diseases affecting other distal organs, such as the BBB. However, the interplay between pesticides, microbiota, the IB, and the BBB is still not fully explored. In this review, we first consider the similarities/differences between these two physiological barriers and the different pathways that link the gut microbiota and the BBB to better understand the dialogue between bacteria and the brain. We then discuss the effects of chronic oral pesticide exposure on the gut-microbiota-BBB axis and raise awareness of the danger of chronic exposure, especially during the perinatal period (pregnant women and offspring).
越来越多的证据表明，长期接触饮食中低水平的农药会影响人体肠道微生物群-血脑屏障（BBB）轴。该轴描述了微生物群、肠屏障（IB）和 BBB 之间的生理和双向连接。临床前观察报告了农药引起的肠道微生物改变，也称为肠道菌群失调，这种情况不仅与胃肠道疾病有关，还与影响其他远端器官的疾病有关，如 BBB。然而，农药、微生物群、IB 和 BBB 之间的相互作用仍未被充分探索。在这篇综述中，我们首先考虑了这两个生理屏障的相似之处/差异以及连接肠道微生物群和 BBB 的不同途径，以更好地理解细菌和大脑之间的对话。然后，我们讨论了慢性口服农药暴露对肠道微生物群-血脑屏障轴的影响，并提高了对慢性暴露危险的认识，特别是在围产期（孕妇和后代）。
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