来自柳珊瑚科柳珊瑚属（Briareum sp.）的新型9-羟基刺柏烷二萜类化合物。

New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae).

作者信息

Su Yin-Di, Sung Chun-Sung, Wen Zhi-Hong, Chen Yu-Hsin, Chang Yu-Chia, Chen Jih-Jung, Fang Lee-Shing, Wu Yang-Chang, Sheu Jyh-Horng, Sung Ping-Jyun

机构信息

Department of Marine Biotechnology & Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.

出版信息

Int J Mol Sci. 2016 Jan 9;17(1):79. doi: 10.3390/ijms17010079.

DOI:10.3390/ijms17010079

PMID:26761004

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4730323/

Abstract

Six new 9-hydroxybriarane diterpenoids, briarenolides ZI-ZVI (1-6), were isolated from a gorgonian coral Briareum sp. The structures of briaranes 1-6 were elucidated by spectroscopic methods and by comparison of their spectroscopic data with those of related analogues. Briarenolides ZII (2) and ZVI (6) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.

摘要

从柳珊瑚属（Briareum sp.）的一种海扇珊瑚中分离出了6种新的9-羟基刺柏烷二萜类化合物，即刺柏内酯ZI-ZVI（1-6）。通过光谱方法并将它们的光谱数据与相关类似物的数据进行比较，阐明了刺柏烷1-6的结构。发现刺柏内酯ZII（2）和ZVI（6）能显著抑制脂多糖（LPS）刺激的RAW264.7巨噬细胞中促炎诱导型一氧化氮合酶（iNOS）蛋白的表达。