部分门静脉结扎对肝再生的影响。
Effect of partial portal vein ligation on hepatic regeneration.
作者信息
Kahn D, Kajani M, Zeng Q, Lai H S, Eagon P K, Makowka L, Starzl T E, Van Thiel D H
机构信息
Department of Surgery, University of Pittsburgh School of Medicine, PA 15261.
出版信息
J Invest Surg. 1988;1(4):267-76. doi: 10.3109/08941938809141092.
To evaluate the effect of portal hypertension and diminished portal venous blood flow to the liver on hepatic regeneration, male rats were subjected to partial portal vein ligation and subsequently to a two-thirds partial hepatectomy. The levels of ornithine decarboxylase activity at 6 h after partial hepatectomy were greater (p less than 0.001) in the rats with prior partial portal vein ligation than in those without portal hypertension. The rats with prior partial portal vein ligation also had greater (p less than 0.005) levels of thymidine kinase activity at 48 h after partial hepatectomy than did those without portal hypertension. Hepatic sex hormone receptor activity was not affected by prior partial portal vein ligation either before or after partial hepatectomy. The reductions in both estrogen and androgen receptor activity observed in the hepatic cytosol after partial hepatectomy were similar to those observed in control animals. These data indicate that animals with portal hypertension having a diminished hepatic portal blood flow have a normal capacity to regenerate hepatic mass following a hepatic resection.
为评估门静脉高压和进入肝脏的门静脉血流减少对肝再生的影响，对雄性大鼠进行部分门静脉结扎，随后进行三分之二肝部分切除术。部分肝切除术后6小时，先前接受部分门静脉结扎的大鼠的鸟氨酸脱羧酶活性水平高于未患门静脉高压的大鼠（p<0.001）。先前接受部分门静脉结扎的大鼠在部分肝切除术后48小时的胸苷激酶活性水平也高于未患门静脉高压的大鼠（p<0.005）。部分肝切除术前或术后，先前的部分门静脉结扎均未影响肝脏性激素受体活性。部分肝切除术后在肝细胞溶胶中观察到的雌激素和雄激素受体活性降低与在对照动物中观察到的相似。这些数据表明，患有门静脉高压且肝门静脉血流减少的动物在肝切除术后具有正常的肝质量再生能力。
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