在缺乏门静脉血流的肝实质中增殖反应的发展。
The development of a proliferative response in liver parenchyma deprived of portal blood flow.
作者信息
Weinbren K, Stirling G A, Washington S L
出版信息
Br J Exp Pathol. 1972 Feb;53(1):54-8.
Abstract
A hyperplastic response develops in portal-deprived liver tissue when 90 per cent of the portal blood flow is deviated, and to a much lesser extent when 67 per cent of the portal blood flow is deviated to the remaining posterior liver lobes. This wave of mitoses develops later than that which occurs in unligated liver tissue. The findings are considered to represent a situation in which haemodynamic effects have been excluded from the development of hepatocyte proliferation. They support the contention that the hepatic proliferative response is, in part at any rate, effected by a humoral mechanism.
摘要
当90%的门静脉血流被分流时，门静脉供血不足的肝组织会出现增生反应；而当67%的门静脉血流被分流至剩余的肝后叶时，增生反应程度要小得多。这种有丝分裂波比未结扎肝脏组织中出现的有丝分裂波发展得更晚。这些发现被认为代表了一种情况，即血流动力学效应在肝细胞增殖的发生过程中被排除在外。它们支持了这样一种观点，即肝脏的增殖反应至少部分是由体液机制介导的。
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