Evaluation of combined excimer laser and platelet-rich plasma for the treatment of nonsegmental vitiligo: A prospective comparative study.

BACKGROUND

Excimer laser therapy of vitiligo generally takes months to years to achieve excellent outcomes. Platelet-rich plasma is an autologous preparation with a focus on various growth factors that can help with vitiligo repigmentation.

OBJECTIVES

To assess the additive effect of PRP in the therapy of vitiligo on the results of the excimer laser.

PATIENTS AND METHODS

A comparative study included 52 patients (8 males and 44 females) in two groups with stable (no new lesion for 6 months), nonsegmental and symmetrical vitiligo. Group I (26 patients): The patient was treated by intradermal PRP injection and the excimer laser, while group II (26 patients) was treated with the excimer laser only. The PRP injection was repeated every 3 weeks for 4 months and excimer laser two times a week and for 16 weeks till complete response. VAS for patient's satisfaction assessment, safety assessment for complications, and follow-up for 3 months was done. Clinical (repigmentation response) and histopathological assessment was done.

RESULTS

There was a higher statistically significant treatment response in group I compared with group II. In addition, a statistically significant correlation between the treatment response and the lesion site in group I (P < .000). A significant difference in VAS between both groups (P < .000). Few the side effects were reported.

CONCLUSION

The combination of PRP and excimer laser phototherapy is an efficient vitiligo treatment as PRP increases the excimer laser impact and also improves the result.