Faculty of Science, Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva 30 quai Ernest Ansermet, CH-1205 Geneva, Switzerland.
Faculty of Science, Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva 30 quai Ernest Ansermet, CH-1205 Geneva, Switzerland.
Curr Opin Chem Biol. 2019 Oct;52:112-124. doi: 10.1016/j.cbpa.2019.06.006. Epub 2019 Sep 18.
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability of hybridization complexes (either as duplexes or triplexes), metabolic stability, and ease of chemical modifications. These features have enabled important applications such as antisense agents, gene editing, nucleic acid sensing and as a platform to program the assembly of PNA-tagged molecules. Here, we review recent advances in these areas.
肽核酸（PNA）是最成功的人工寡核苷酸类似物之一。其显著特点包括杂交复合物（双链体或三链体）的稳定性、代谢稳定性和易于化学修饰。这些特性使其在反义试剂、基因编辑、核酸传感以及作为一种平台来设计 PNA 标记分子的组装等方面具有重要的应用。本文综述了这些领域的最新进展。
