Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, Denmark.
Neurobiology Research Unit, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Clin Neurophysiol. 2019 Nov;130(11):2060-2064. doi: 10.1016/j.clinph.2019.08.007. Epub 2019 Aug 22.
To investigate the effect of spatial sampling and of recording duration on the diagnostic yield of EEG for identification of interictal epileptiform discharges (IEDs). Previous studies demonstrated that high-density (HD) recordings increased accuracy of localization compared to low-density (LD) recordings.
We have prospectively evaluated the effect of spatial sampling and of recording duration in patients who had short-term (ST) recordings with a HD array of 256 electrodes following long-term (LT) recordings with a LD array consisting of the standard IFCN array of 25 electrodes. IED clusters were identified in four datasets: LT-LD, ST-LD (spatially down-sampled to the standard IFCN array), ST-HD and a shortened (90 minutes) epoch of LT-LD.
Sixty consecutive patients were recruited. We identified 89 IED clusters totally. Two clusters were found by increasing spatial sampling from 25 to 256 electrodes. This modest increase was not statistically significant. Eight clusters were missed by reducing the recording duration to 90 minutes, as compared with the LT recordings (p = 0.003).
Recording duration is more important for the diagnostic yield of EEGs than increasing spatial sampling beyond the standard IFCN electrode array.
The standard IFCN electrode array provides sufficient spatial sampling for identification of the IEDs.
研究空间采样和记录时长对脑电图（EEG）识别发作间期棘波（IEDs）的诊断效果的影响。先前的研究表明，高密度（HD）记录与低密度（LD）记录相比，提高了定位的准确性。
我们前瞻性地评估了空间采样和记录时长对患者的影响，这些患者在使用 256 个电极的高密度阵列进行短期（ST）记录后，接着使用由标准 IFCN 阵列的 25 个电极组成的长期（LT）低密度阵列进行记录。在四个数据集（LT-LD、ST-LD（空间下采样至标准 IFCN 阵列）、ST-HD 和 LT-LD 的缩短（90 分钟）时段）中识别 IED 簇。
共招募了 60 名连续患者。我们总共确定了 89 个 IED 簇。通过将空间采样从 25 个电极增加到 256 个电极，发现了两个簇。这种适度的增加在统计学上并不显著。与 LT 记录相比，将记录时长缩短至 90 分钟时，错过了 8 个簇（p=0.003）。
与增加空间采样超过标准 IFCN 电极阵列相比，记录时长对 EEG 的诊断效果更为重要。
标准 IFCN 电极阵列为识别 IED 提供了足够的空间采样。
