Witkoff Benjamin M, Ivanov Nedyalko N, Trotter Shannon C
Ohio University Heritage College of Osteopathic Medicine, Athens, Ohio, USA.
Private Practice Oakview Dermatology, Springfield, Ohio, USA.
Case Rep Dermatol. 2019 Aug 6;11(2):233-238. doi: 10.1159/000501875. eCollection 2019 May-Aug.
We present a 54-year-old Caucasian female with a history of diabetes mellitus, multiple sclerosis, and ulcerative colitis who presented with nail dystrophy, polyarthralgia in her hands and hips, myalgia, proximal myopathy, dactylitis, and psoriasiform-appearing progressive, painful plaques on the dorsal aspect of her hands. Histologic examination of the lesion from the left index finger revealed an interstitial and necrobiotic granulomatous dermatitis with connective tissue mucin deposition associated with a perivascular lymphoid infiltrate. Additionally, there was focal transepidermal elimination of the necrobiotic material. She was diagnosed with perforating granuloma annulare (PGA). We are unaware of any other cases of PGA in the literature with this presentation.
我们报告一名54岁的白种女性,有糖尿病、多发性硬化症和溃疡性结肠炎病史,出现了甲营养不良、手部和髋部多关节痛、肌痛、近端肌病、指(趾)炎以及手部背侧出现银屑病样外观的进行性疼痛斑块。对左手食指病变进行组织学检查,显示为间质性和坏死性肉芽肿性皮炎,伴有结缔组织黏蛋白沉积,并有血管周围淋巴细胞浸润。此外,有坏死物质的局灶性经表皮排出。她被诊断为穿通性环状肉芽肿(PGA)。我们未在文献中发现有此表现的其他PGA病例。