Ghapanchi Jannan, Emami Amir, Rezazadeh Fahimeh, Shakibasefat Hajar, Pirbonyeh Neda
Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Microbiology, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Dent Res J (Isfahan). 2019 Sep 5;16(5):333-337. eCollection 2019 Sep-Oct.
Liver transplantation has turn into a standard management for chronic liver failure (CLF), and the number of recipients increased during the last few years. Enterococci are progressively related to nosocomial and opportunistic infections. Oral cavity may act as a reservoir for this species, especially in cases with oral infection. Immunocompromised patients are prone to serious enterococci-related disease. This study investigated the prevalence of in the saliva samples of patient candidates for liver transplantation.
In this cross-sectional study the saliva samples of 100 patient candidates for liver transplantation and 100 age- and sex-matched healthy control group were collected. Bacterial DNA was extracted from the samples and was detected using polymerase chain reaction test. Fisher's exact test and Mann-Whitney test were used to correlate the positive and negative cases with the disease. Statistically, a significant difference was considered when < 0.05.
There was no significant difference between both groups for the presence of . This bacterium isolated from the saliva of two cases in the study group and only one healthy control. The higher rate of carious teeth were detected in the oral cavity of CLF cases than control group ( = 0.001).
Patients with chronic liver diseases assessed in this research showed a higher incidence of poor oral health and caries compared with the healthy controls, but there was no statistical difference in the presence of in saliva samples of each group. Complete oral examination, dental treatment, and oral hygiene instruction are necessary for all these cases before liver transplantation.
肝移植已成为慢性肝衰竭（CLF）的标准治疗方法，在过去几年中接受者数量有所增加。肠球菌与医院感染和机会性感染的相关性日益增加。口腔可能是该菌种的储存库，尤其是在口腔感染的情况下。免疫功能低下的患者容易发生严重的肠球菌相关疾病。本研究调查了肝移植候选患者唾液样本中[具体菌种未提及]的患病率。
在这项横断面研究中，收集了100例肝移植候选患者和100例年龄及性别匹配的健康对照组的唾液样本。从样本中提取细菌DNA，并使用聚合酶链反应试验检测[具体菌种未提及]。采用Fisher精确检验和Mann-Whitney检验将阳性和阴性病例与疾病进行关联。统计学上，当P<0.05时认为存在显著差异。
两组在[具体菌种未提及]的存在方面没有显著差异。在研究组的两例患者唾液中分离出该细菌，而在健康对照组中仅分离出一例。CLF病例口腔中龋齿发生率高于对照组（P = 0.001）。
本研究中评估的慢性肝病患者与健康对照组相比，口腔健康不良和龋齿的发生率更高，但每组唾液样本中[具体菌种未提及]的存在情况没有统计学差异。在所有这些病例进行肝移植之前，进行全面的口腔检查、牙科治疗和口腔卫生指导是必要的。
