Maternity School Assis Chateaubriand, Federal University of Ceará (UFC) (Drs. Pinto Medeiros Dias, Monteiro Bilhar, Cunha Rios, and Pinheiro Sobreira Bezerra), Fortaleza, CE, Brazil.
Maternity School Assis Chateaubriand, Federal University of Ceará (UFC) (Drs. Pinto Medeiros Dias, Monteiro Bilhar, Cunha Rios, and Pinheiro Sobreira Bezerra), Fortaleza, CE, Brazil; Drug Research and Development Center, Federal University of Ceará (UFC) (Drs. Almeida Costa and Odorico de Moraes Filho), Fortaleza, CE, Brazil.
J Minim Invasive Gynecol. 2020 May-Jun;27(4):966-972. doi: 10.1016/j.jmig.2019.09.779. Epub 2019 Sep 20.
Mayer-Rokitansky-Küster-Hauser syndrome is the second most common cause of primary amenorrhea, trailing only to gonadal dysgenesis. Neovaginoplasty is an appropriate treatment option for patients who have failed dilation therapy. Several biomaterials have been used in this procedure, including peritoneum, amnion, skin grafts, and myocutaneous flaps. Nile Tilapia Fish Skin has noninfectious microbiota, morphologic structure comparable to human skin, and high in vivo bioresorption. In addition, it showed good outcomes when used as a xenograft for burn treatment. Thus, we suggest it as a new biologic graft for vaginal agenesis management. In this descriptive study, neovaginoplasty using Nile Tilapia Fish Skin offered 3 patients an anatomic and functional neovagina via a simple method with potential long-term effectiveness. When postsurgical dilation was performed correctly, a vaginal length greater than 6 cm was maintained at 180 days follow-up. Histologic and immunohistochemical analyses revealed the presence of stratified squamous epithelium with high expression of cytokeratins and fibroblast growth factor, matching the characteristics of normal adult vaginal tissue. We believe that further studies will show Nile Tilapia Fish Skin to be a relevant option in the therapeutic arsenal of Mayer-Rokitansky-Küster-Hauser syndrome.
苗勒管发育不全-罗氏综合征是原发性闭经的第二大常见原因，仅次于性腺发育不全。对于未能通过扩张治疗成功的患者，阴道成形术是一种合适的治疗选择。在该手术中已经使用了多种生物材料，包括腹膜、羊膜、皮肤移植物和肌皮瓣。尼罗罗非鱼皮无传染性微生物群，其形态结构与人体皮肤相似，并且体内生物吸收性高。此外，它在用于烧伤治疗的异种移植物中显示出良好的效果。因此，我们建议将其作为阴道发育不全管理的新型生物移植物。在这项描述性研究中，尼罗罗非鱼皮阴道成形术为 3 名患者提供了一种通过简单方法实现的解剖学和功能性新阴道，具有潜在的长期有效性。当术后扩张正确进行时，在 180 天的随访中保持阴道长度大于 6 厘米。组织学和免疫组织化学分析显示存在具有高细胞角蛋白和成纤维细胞生长因子表达的复层鳞状上皮，与正常成人阴道组织的特征相匹配。我们相信，进一步的研究将表明尼罗罗非鱼皮是苗勒管发育不全-罗氏综合征治疗武器库中的一个相关选择。
