Sasaki Hiraku, Fukunaga Tomoko, Asano Ai, Suzuki Yoshio, Nakanishi Yuko, Kondo Junzi, Ishikawa Hiroki, Shibata Nobuto
Department of Health Science, Faculty of Health and Sports Science, Juntendo University, 1-1 Hiraga-gakuendai, Inzai, Chiba 270-1695, Japan.
Section of Health Management, Faculty of Health and Sports Science, Juntendo University, 1-1 Hiraga-gakuendai, Inzai, Chiba 270-1695, Japan.
Vaccines (Basel). 2019 Sep 19;7(3):118. doi: 10.3390/vaccines7030118.
In Japan, sporadic measles cases increased rapidly in 2019 compared to the past six years. To clarify the persistence of immunity against measles in young adults, this study explored the persistence of immunoglobulin G (IgG) antibody titers against the measles virus in 17- to 24-year-old young participants who reside in the Chiba prefecture of Japan. Measles-specific IgG antibody titers, determined by enzyme immunoassay in serum samples collected from 506 participants, were assessed through statistical analyses. Multivariable regression analysis revealed that the distribution of measles IgG antibody titers was significantly correlated with a medical history of measles ( < 0.05), while there was no significant correlation between the number of vaccinations related to measles IgG titers. Furthermore, measles IgG titers tended to decrease, as revealed by the temporal change in IgG titers, during the elapsed period after the last vaccination ( = 0.08). These results indicate that periodic vaccination against measles is required to prevent sporadic measles infection in young and older adults.
在日本，与过去六年相比，2019年散发性麻疹病例迅速增加。为了阐明年轻成年人中麻疹免疫的持久性，本研究探讨了居住在日本千叶县的17至24岁年轻参与者中针对麻疹病毒的免疫球蛋白G（IgG）抗体滴度的持久性。通过对从506名参与者收集的血清样本进行酶免疫测定来确定麻疹特异性IgG抗体滴度，并通过统计分析进行评估。多变量回归分析显示，麻疹IgG抗体滴度的分布与麻疹病史显著相关（<0.05），而与麻疹IgG滴度相关的疫苗接种次数之间没有显著相关性。此外，如IgG滴度的时间变化所示，在最后一次接种疫苗后的一段时间内，麻疹IgG滴度有下降趋势（=0.08）。这些结果表明，需要定期接种麻疹疫苗以预防年轻人和老年人中的散发性麻疹感染。
