Ogawa Taku, Uchiyama-Nakamura Fukumi, Sugata-Tsubaki Aiko, Yamada Yutaka, Uno Kenji, Kasahara Kei, Maeda Koichi, Konishi Mitsuru, Mikasa Keiichi
Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522 Japan . Tel: +81-744-22-3051 (ext. 3525).
Center for Infectious Diseases, Nara Medical University, Nara Japan.
Open Med (Wars). 2016 Nov 26;11(1):482-488. doi: 10.1515/med-2016-0085. eCollection 2016.
The purpose of this study was to examine the efficacy rendered with a single dose of live attenuated measles, rubella, mumps, and varicella containing vaccine. We inoculated healthcare workers (HCWs) with a single dose of vaccine to a disease lacking in antibody titer for those not meeting the criteria of our hospital (measles: <16.0 (IgG enzyme immunoassay (EIA)), rubella: ≤1:32 (hemagglutination-inhibition), mumps: <4.0 (IgG EIA), and varicella: <4.0 (IgG EIA)). At 28-60 days after vaccination, the antibody titer was tested again. We included 48 HCWs. A total of 32, 15, 31, and 10 individuals were inoculated with a single dose of measles-containing, rubella-containing, mumps, or varicella vaccine, respectively, and showed significant antibody elevation (9.2 ± 12.3 to 27.6 ± 215.6, p<0.001; 8 ± 1.2 to 32 ± 65.5, p<0.001; 3.0 ± 1.0 to 13.1 ± 8.6, p<0.05; and 2.6 ± 1.3 to 11.8 ± 8.1, p<0.001, respectively). Major side effects were not observed. In a limited population, a single dose of live attenuated vaccine showed elevation of antibody titer without any severe adverse reactions. However, whether the post-vaccination response rate criteria of our university was fulfilled could not be determined owing to limited sample size.
本研究的目的是检验单剂量含减毒活麻疹、风疹、腮腺炎和水痘疫苗的疗效。我们对不符合我院标准（麻疹：<16.0（IgG酶免疫测定（EIA））、风疹：≤1:32（血凝抑制）、腮腺炎：<4.0（IgG EIA）、水痘：<4.0（IgG EIA））且抗体滴度缺乏的疾病的医护人员接种单剂量疫苗。接种疫苗后28 - 60天，再次检测抗体滴度。我们纳入了48名医护人员。分别有32、15、31和10人接种了单剂量含麻疹、含风疹、腮腺炎或水痘疫苗，且抗体显著升高（分别从9.2±12.3升高至27.6±215.6，p<0.001；从8±1.2升高至32±65.5，p<0.001；从3.0±1.0升高至13.1±8.6，p<0.05；从2.6±1.3升高至11.8±8.1，p<0.001）。未观察到主要副作用。在有限的人群中，单剂量减毒活疫苗显示抗体滴度升高且无任何严重不良反应。然而，由于样本量有限，无法确定我校的疫苗接种后反应率标准是否得到满足。
