Oli Angus Nnamdi, Itumo Chimaobi Johnpaul, Okam Princeston Chukwuemeka, Ezebialu Ifeanyichukwu U, Okeke Kenneth Nchekwube, Ifezulike Christian Chukwuemeka, Ezeobi Ifeanyi, Emechebe George Ogonna, Okezie Ugochukwu Moses, Adejumo Samson A, Okoyeh Jude Nnaemeka
Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Agulu, Nnamdi Azikiwe University, Awka 420108, Anambra State, Nigeria.
Department of Pharmacology and Therapeutics, College of Health Sciences, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nnewi 435101, Nigeria.
Antibiotics (Basel). 2019 Sep 20;8(4):156. doi: 10.3390/antibiotics8040156.
The emergence and spread of Carbapenem-resistant (CRE) is seriously posing threats in effective healthcare delivery. The aim of this study was to ascertain the emergence of CRE at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH) Awka. Biological samples were collected from 153 consenting patient from 5 clinics in the hospital. The isolates were identified using standard microbiological protocols. Susceptibility to meropenem was done using Kirby-Bauer disc diffusion method on Mueller Hinton Agar. A total of 153 patients were recruited in this study. About one half of those from rural, 63.64% from Sub-urban and 42.27% from urban areas had significant and spp infections. The male: female ratio of the infection was 1:1. Almost as much inpatient as outpatient study participants had the infections. The infections were observed mostly on participants with lower educational status. The unmarried individuals were most infected compared to their married counterparts. infection rate was 50.98%. Of this, 28.21% had CRE infection while the overall prevalence of the CRE in the studied population was 14.38% (22/153). This study shows that CRE is quickly emerging in both community and hospital environments. spp was the most common CRE in this hospital especially . Hospitalization was a strong risk factor in the CRE infections. Rapid and accurate detection is critical for their effective management and control.
耐碳青霉烯类肠杆菌科细菌（CRE）的出现和传播严重威胁着有效的医疗服务。本研究的目的是确定阿瓦卡的丘库乌梅卡·奥杜梅古·奥朱克武大学教学医院（COOUTH）中CRE的出现情况。从该医院5个诊所的153名同意参与的患者中采集生物样本。使用标准微生物学方案对分离株进行鉴定。采用 Kirby-Bauer 纸片扩散法在 Mueller Hinton 琼脂上检测对美罗培南的敏感性。本研究共招募了153名患者。农村地区约一半、城郊地区63.64%以及城市地区42.27%的患者发生了显著的[具体细菌名称1]和[具体细菌名称2]感染。[具体细菌名称1]感染的男女比例为1:1。住院患者和门诊患者中发生该感染的人数几乎一样多。感染主要发生在教育程度较低的参与者身上。与已婚者相比，未婚者感染最为严重。[具体细菌名称1]感染率为50.98%。其中，28.21%的患者发生了CRE感染，而研究人群中CRE的总体患病率为14.38%（22/153）。本研究表明，CRE正在社区和医院环境中迅速出现。[具体细菌名称2]是该医院最常见的CRE，尤其是[具体细菌名称2的某个类型]。住院是CRE感染的一个重要危险因素。快速准确的检测对于其有效管理和控制至关重要。
