Hahm Eunil, Kang Eun Ji, Pham Xuan-Hung, Jeong Daham, Jeong Dae Hong, Jung Seunho, Jun Bong-Hyun
Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea.
Department of Chemistry Education and Center for Educational Research, Seoul National University, Seoul 08826, Korea.
Nanomaterials (Basel). 2019 Sep 20;9(10):1349. doi: 10.3390/nano9101349.
It has been increasingly important to develop a highly sensitive and selective technique that is easy to handle in detecting levels of beneficial or hazardous analytes in trace quantity. In this study, mono-6-deoxy-6-aminopropylamino--cyclodextrin (pr--CD)-functionalized silver-assembled silica nanoparticles (SiO@Ag@pr--CD) for flavonoid detection were successfully prepared. The presence of pr--CD on the surface of SiO@Ag enhanced the selectivity in capturing quercetin and myricetin among other similar materials (naringenin and apigenin). In addition, SiO@Ag@pr--CD was able to detect quercetin corresponding to a limit of detection (LOD) as low as 0.55 ppm. The relationship between the Raman intensity of SiO@Ag@pr--CD and the logarithm of the Que concentration obeyed linearity in the range 3.4-33.8 ppm (R = 0.997). The results indicate that SiO@Ag@pr--CD is a promising material for immediately analyzing samples that demand high sensitivity and selectivity of detection.
开发一种高度灵敏且选择性高、易于操作的技术，用于检测痕量有益或有害分析物的含量，变得越来越重要。在本研究中，成功制备了用于黄酮检测的单-6-脱氧-6-氨丙基氨基-β-环糊精（pr-β-CD）功能化的银组装二氧化硅纳米颗粒（SiO₂@Ag@pr-β-CD）。SiO₂@Ag表面的pr-β-CD增强了在其他类似物质（柚皮苷和芹菜素）中捕获槲皮素和杨梅素的选择性。此外，SiO₂@Ag@pr-β-CD能够检测出低至0.55 ppm的检测限对应的槲皮素。SiO₂@Ag@pr-β-CD的拉曼强度与槲皮素浓度的对数之间的关系在3.4 - 33.8 ppm范围内呈线性（R = 0.997）。结果表明，SiO₂@Ag@pr-β-CD是一种有前景的材料，可用于即时分析需要高灵敏度和选择性检测的样品。
