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一例犬类类鼻疽成功治疗与管理

Successful Treatments and Management of A Case of Canine Melioidosis.

作者信息

Khrongsee Pacharapong, Lueangthuwapranit Chulalak, Ingkasri Thitsana, Sretrirutchai Somporn, Kaewrakmuk Jedsada, Saechan Vannarat, Tuanyok Apichai

机构信息

Faculty of Veterinary Science, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand.

Department of Infectious Diseases and Immunology, College of Veterinary Medicine, and the Emerging Pathogens Institute, University of Florida, Gainesville, FL 32608, USA.

出版信息

Vet Sci. 2019 Sep 23;6(4):76. doi: 10.3390/vetsci6040076.

DOI:10.3390/vetsci6040076
PMID:31547534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6958349/
Abstract

This communication presents a successful story of an attempt to treat and manage a case of canine melioidosis, a severe tropical disease caused by A 10-year-old dog was trapped with barbed wires, causing an infected wound around its neck and back, which was later diagnosed as severe melioidosis. The dog was treated based on a modified human protocol. Intravenous meropenem injections (20 mg/kg twice daily) were given for 14 days to prevent death from sepsis prior to treatment with oral sulfamethoxazole-trimethoprim (25 mg/kg twice daily) for 20 weeks to eliminate the bacteria. Canine melioidosis is an unusual infection in dogs, even in Thailand where melioidosis is highly endemic. This successful case management was solely based on proper diagnosis and appropriate treatments.

摘要

本通讯介绍了一例犬类类鼻疽治疗与管理的成功案例,类鼻疽是一种由[细菌名称未给出]引起的严重热带疾病。一只10岁的狗被铁丝网困住,导致其颈部和背部出现感染伤口,后来被诊断为严重类鼻疽。这只狗按照改良的人类治疗方案进行治疗。在使用口服磺胺甲恶唑-甲氧苄啶(25毫克/千克,每日两次)治疗20周以消除细菌之前,先静脉注射美罗培南(20毫克/千克,每日两次)14天,以防止败血症导致死亡。犬类类鼻疽在狗身上是一种不常见的感染,即使在类鼻疽高度流行的泰国也是如此。这个成功的病例管理完全基于正确的诊断和适当的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a46b/6958349/5776ccd0aa0d/vetsci-06-00076-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a46b/6958349/5776ccd0aa0d/vetsci-06-00076-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a46b/6958349/5776ccd0aa0d/vetsci-06-00076-g001.jpg

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本文引用的文献

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Melioidosis in Thailand: Present and Future.泰国的类鼻疽:现状与未来。
Trop Med Infect Dis. 2018;3(2):38. doi: 10.3390/tropicalmed3020038. Epub 2018 Apr 8.
2
Public health response to an imported case of canine melioidosis.对一例输入性犬类类鼻疽病例的公共卫生应对措施。
Zoonoses Public Health. 2018 Jun;65(4):420-424. doi: 10.1111/zph.12450. Epub 2018 Feb 16.
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Treatment and prophylaxis of melioidosis.类鼻疽的治疗与预防。
Int J Antimicrob Agents. 2014 Apr;43(4):310-8. doi: 10.1016/j.ijantimicag.2014.01.005. Epub 2014 Feb 3.
4
Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial.复方磺胺甲噁唑与复方磺胺甲噁唑联合多西环素作为口服根除治疗类鼻疽(MERTH)的疗效比较:一项多中心、双盲、非劣效性、随机对照临床试验。
Lancet. 2014 Mar 1;383(9919):807-14. doi: 10.1016/S0140-6736(13)61951-0. Epub 2013 Nov 25.
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PLoS Negl Trop Dis. 2013;7(3):e2105. doi: 10.1371/journal.pntd.0002105. Epub 2013 Mar 21.
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Melioidosis in animals, Thailand, 2006-2010.2006-2010 年泰国动物中的类鼻疽病。
Emerg Infect Dis. 2012 Feb;18(2):325-7. doi: 10.3201/eid1802.111347.
7
Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis.血培养重复检出鼻疽伯克霍尔德菌表明患类鼻疽的死亡风险增加。
Am J Trop Med Hyg. 2011 Jun;84(6):858-61. doi: 10.4269/ajtmh.2011.10-0618.
8
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J Clin Microbiol. 2003 May;41(5):2068-79. doi: 10.1128/JCM.41.5.2068-2079.2003.
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