Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco (UAM-Xochimilco), Calzada del Hueso No. 1100, CdMx 04960, Mexico.
Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida IPN No. 2508, CdMx 07360, Mexico.
Int J Mol Sci. 2019 Sep 23;20(19):4707. doi: 10.3390/ijms20194707.
Lactoferrin (Lf) is an iron-binding milk glycoprotein that promotes the growth of selected probiotic strains. The effect of Lf on the growth and diversification of intestinal microbiota may have an impact on several issues, including (i) strengthening the permeability of the epithelial cell monolayer, (ii) favoring the microbial antagonism that discourages the colonization and proliferation of enteric pathogens, (iii) enhancing the growth and maturation of cell-monolayer components and gut nerve fibers, and (iv) providing signals to balance the anti- and pro-inflammatory responses resulting in gut homeostasis. Given the beneficial role of probiotics, this contribution aims to review the current properties of bovine and human Lf and their derivatives in in vitro probiotic growth and Lf interplay with microbiota described in the piglet model. By using Lf as a component in pharmacological products, we may enable novel strategies that promote probiotic growth while conferring antimicrobial activity against multidrug-resistant microorganisms that cause life-threatening diseases, especially in neonates.
乳铁蛋白（Lf）是一种铁结合的乳球蛋白，可促进选定益生菌株的生长。Lf 对肠道微生物群的生长和多样化的影响可能对几个问题产生影响，包括（i）增强上皮细胞单层的通透性，（ii）有利于抑制肠道病原体定植和增殖的微生物拮抗作用，（iii）促进细胞单层成分和肠道神经纤维的生长和成熟，以及（iv）提供平衡抗炎症和促炎症反应的信号，从而维持肠道内环境稳态。鉴于益生菌的有益作用，本研究旨在综述牛和人乳铁蛋白及其衍生物在体外益生菌生长中的作用及其与仔猪模型中肠道微生物群相互作用的最新特性。通过将 Lf 用作药物产品的成分，我们可以开发新的策略，在促进益生菌生长的同时，对引起危及生命疾病的多药耐药微生物具有抗菌活性，特别是在新生儿中。
