Koo J Y, Park B C, Chung J M
Korean J Intern Med. 1987 Jul;2(2):221-6. doi: 10.3904/kjim.1987.2.2.221.
The present study was to address the nature of cells which are responsible for enhanced spontaneous lymphocyte transformation (SLT) observed in patients with HBsAg-positive chronic active hepatitis (CAH). The subjects consisted of 34 cases with HBsAg-positive CAH (group I), 31 HBsAg carrier (group II), and 27 normal persons (group III) who had no serological evidence of hepatitis B virus (HBV) infection. SLT values and the number of cells bearing HLA-DR antigens in group I (1021.45±276.40 cpm, 36.94±4.90%) were significantly (p<0.01) elevated as compared to group II (103.74±30.44 cpm, 13.26± 4.72%) and III (118.92 ± 30.84 cpm, 14.93±5.10%), but there was no difference of the number of the IL-2 receptor-bearing cells among each groups. Though natural killer (NK) cell activity in both group I (65.42±15.77%) and II (59.14±14.89%) were significantly enhanced as compared to group III (46.25±20.20%), there was no difference in between group I and II. These findings indicate that the cells bearing HLA-DR antigen, but not NK cells, are responsible for the enhanced SLT in patients with CAH.
本研究旨在探讨在HBsAg阳性慢性活动性肝炎(CAH)患者中观察到的增强的自发淋巴细胞转化(SLT)所涉及的细胞性质。研究对象包括34例HBsAg阳性CAH患者(第一组)、31例HBsAg携带者(第二组)和27例无乙肝病毒(HBV)感染血清学证据的正常人(第三组)。与第二组(103.74±30.44 cpm,13.26±4.72%)和第三组(118.92±30.84 cpm,14.93±5.10%)相比,第一组的SLT值和携带HLA-DR抗原的细胞数量(1021.45±276.40 cpm,36.94±4.90%)显著升高(p<0.01),但各组间携带IL-2受体的细胞数量无差异。尽管第一组(65.42±15.77%)和第二组(59.14±14.89%)的自然杀伤(NK)细胞活性均显著高于第三组(46.25±20.20%),但第一组和第二组之间无差异。这些发现表明,携带HLA-DR抗原的细胞而非NK细胞,是导致CAH患者SLT增强的原因。