Suppr超能文献

乙肝表面抗原阳性慢性活动性肝炎患者的免疫学研究——自发淋巴细胞转化和自然杀伤细胞活性

Immunological studies in patients with HBsAg-positive chronic active hepatitis--spontaneous lymphocyte transformation and natural killer cell activity.

作者信息

Koo J Y, Park B C, Chung J M

出版信息

Korean J Intern Med. 1987 Jul;2(2):221-6. doi: 10.3904/kjim.1987.2.2.221.

Abstract

The present study was to address the nature of cells which are responsible for enhanced spontaneous lymphocyte transformation (SLT) observed in patients with HBsAg-positive chronic active hepatitis (CAH). The subjects consisted of 34 cases with HBsAg-positive CAH (group I), 31 HBsAg carrier (group II), and 27 normal persons (group III) who had no serological evidence of hepatitis B virus (HBV) infection. SLT values and the number of cells bearing HLA-DR antigens in group I (1021.45±276.40 cpm, 36.94±4.90%) were significantly (p<0.01) elevated as compared to group II (103.74±30.44 cpm, 13.26± 4.72%) and III (118.92 ± 30.84 cpm, 14.93±5.10%), but there was no difference of the number of the IL-2 receptor-bearing cells among each groups. Though natural killer (NK) cell activity in both group I (65.42±15.77%) and II (59.14±14.89%) were significantly enhanced as compared to group III (46.25±20.20%), there was no difference in between group I and II. These findings indicate that the cells bearing HLA-DR antigen, but not NK cells, are responsible for the enhanced SLT in patients with CAH.

摘要

本研究旨在探讨在HBsAg阳性慢性活动性肝炎(CAH)患者中观察到的增强的自发淋巴细胞转化(SLT)所涉及的细胞性质。研究对象包括34例HBsAg阳性CAH患者(第一组)、31例HBsAg携带者(第二组)和27例无乙肝病毒(HBV)感染血清学证据的正常人(第三组)。与第二组(103.74±30.44 cpm,13.26±4.72%)和第三组(118.92±30.84 cpm,14.93±5.10%)相比,第一组的SLT值和携带HLA-DR抗原的细胞数量(1021.45±276.40 cpm,36.94±4.90%)显著升高(p<0.01),但各组间携带IL-2受体的细胞数量无差异。尽管第一组(65.42±15.77%)和第二组(59.14±14.89%)的自然杀伤(NK)细胞活性均显著高于第三组(46.25±20.20%),但第一组和第二组之间无差异。这些发现表明,携带HLA-DR抗原的细胞而非NK细胞,是导致CAH患者SLT增强的原因。

相似文献

2
Immunological aspects of chronic active hepatitis.
Hepatology. 1983 Sep-Oct;3(5):724-8. doi: 10.1002/hep.1840030517.
5
Effect of prednisone on DR-positive T cells in children with chronic active hepatitis B.
J Pediatr Gastroenterol Nutr. 1989 Apr;8(3):288-91. doi: 10.1097/00005176-198904000-00004.
9
Active rosette-forming lymphocytes in chronic hepatitis.
Med Interne. 1982 Oct-Dec;20(4):277-82.

引用本文的文献

1
Natural killing activities in chronic liver diseases and hepatocellular carcinoma.
J Clin Immunol. 1996 Jan;16(1):41-5. doi: 10.1007/BF01540971.

本文引用的文献

1
Natural killer cells: their roles in defenses against disease.
Science. 1981 Oct 2;214(4516):24-30. doi: 10.1126/science.7025208.
2
Type B hepatitis: progression to chronic hepatitis.
Clin Gastroenterol. 1980 Jan;9(1):97-115.
3
Increased circulating Ia-bearing T cells in HBsAg-positive chronic active hepatitis.
N Engl J Med. 1982 Aug 19;307(8):501-2. doi: 10.1056/NEJM198208193070818.
8
Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells.
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2172-5. doi: 10.1073/pnas.81.7.2172.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验